Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE These results suggest that the STAT3 pathway is associated with the mTOR downstream pathway mediated by YKL-40 protein, and the combination therapy of the STAT3 inhibitor and rapamycin could be worth developing as a novel therapeutic approach against TMZ-resistant relapsed gliomas. 28031240 2017
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression disease BEFREE Findings presented in our study showed that increased mRNA level of CHI3L1 could be associated with the progression of astrocytoma and poor patient survival not only for glioblastoma, but for lower grade astrocytoma tumors as well. 27121858 2016
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker disease BEFREE Extraneural metastases in glioblastoma patients: two cases with YKL-40-positive glioblastomas and a meta-analysis of the literature. 26212701 2016
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE High CHI3L1 expression is associated with glioma patient survival. 27121858 2016
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker disease BEFREE YKL-40 downregulation is a key factor to overcome temozolomide resistance in a glioblastoma cell line. 24842123 2015
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression disease BEFREE OSM enhanced transcript and protein level of fibronectin and YKL-40 and reduced the expression of Olig2 and DLL3 in GBM cells. 25748242 2015
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression disease BEFREE In this paper, the authors' goal was to evaluate the prognostic value of YKL-40 expression as a prognostic factor for glioblastomas and to compare its validity to the already known MGMT. 22655594 2012
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker disease BEFREE Fitting models with and without YKL-40 highlights a subgroup of patients who have glioblastoma (GBM) diagnosis but appear to have better prognosis than the typical GBM patient. 22495652 2012
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression disease BEFREE Although YKL-40 expression is up-regulated in glioblastoma multiforme, its regulation and functions in nontransformed cells of the central nervous system are widely unexplored. 21953450 2012
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the secreted glycoprotein YKL-40. 21953450 2012
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker disease BEFREE Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma. 21385870 2011
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker disease CTD_human Resveratrol represses YKL-40 expression in human glioma U87 cells. 21029458 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease CTD_human Thus, targeting the CHI3L1 molecule may be a potential therapeutic molecular target for gliomas. 20506295 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease CTD_human CHI3L1 suppression by shRNA reduced glioma cell invasion, anchorage-independent growth and increased cell death triggered by several anticancer drugs, including cisplatin, etoposide and doxorubicin, whereas CHI3L1 overexpression had the opposite effect in glioma cells. 20506295 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease CTD_human Because the invasive nature of glioma cells plays a critical role in the high morbidity of glioma, we have further defined the role of CHI3L1 in the process of glioma invasion. 20506295 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE CHI3L1 (YKL-40) is expressed in human gliomas and regulates the invasion, growth and survival of glioma cells. 20506295 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease CTD_human In our study, we examined the expression and function of CHI3L1 in glioma cells. 20506295 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease CTD_human Taken together, these results suggest that CHI3L1 plays an important role in the regulation of malignant transformation and local invasiveness in gliomas. 20506295 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease CTD_human Furthermore, the expression and activity of matrix metalloproteinase-2 was also decreased in glioma cells in which CHI3L1 was knocked down. 20506295 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease CTD_human CHI3L1 (YKL-40) is expressed in human gliomas and regulates the invasion, growth and survival of glioma cells. 20506295 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease CTD_human CHI3L1 was highly expressed in human glioma tissue, whereas its expression in normal brain tissue was very low. 20506295 2011
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression disease BEFREE The objective of this study was to evaluate, in a series of 43 pediatric high-grade gliomas (21 anaplastic astrocytoma WHO grade III and 22 glioblastoma WHO grade IV), the prognostic value of histological grading and expression of p53 and YKL-40. 20174854 2010
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker disease BEFREE YKL-40 is directly produced by tumor cells and is inversely linked to EGFR in glioblastomas. 20224722 2010
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression disease BEFREE The YKL-40 coding chitinase 3-like 1 gene is 1 of the most overexpressed genes in human glioblastomas. 20499402 2010
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE YKL-40 mRNA was abundant in glioma cells as well as reactive astrocytes, but was low in admixed neurons and macrophages. 20224722 2010