Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 Biomarker group BEFREE RASSF1A deficiency profoundly enhanced the development of K-RAS-driven lung tumors <i>in vivo</i> Analysis of these tumors showed loss of RASSF1A-uncoupled RAS from the proapoptotic Hippo pathway as expected. 29735543 2018
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 AlteredExpression group BEFREE Using stable clones of two human lung tumor cell lines (NCI-H1792 and NCI-H1299) with shRNA-mediated silencing or ectopic overexpression of RASSF1A, we show that activated Rheb stimulates the Hippo pathway, but is suppressed in its ability to stimulate the TOR pathway. 27034171 2016
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 Biomarker group BEFREE Collectively, our results indicated that RASSF1 acts to restrict EMT and invasion by indirectly controlling YAP nuclear shuttling and activation through a RhoB-regulated cytoskeletal remodeling process, with potential implications to delay the progression of RASSF1-hypermethylated lung tumors. 26759237 2016
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 AlteredExpression group BEFREE High percentage of lung tumor samples with simultaneous RASSF1A decreased expression and gene promoter methylation indicates its epigenetic silencing. 26112163 2015
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 Biomarker group BEFREE RASSF1A, a candidate tumor suppressor gene, recently cloned from the lung tumor locus at 3p21.3, is frequently inactivated by hypermethylation of its promoter region in a number of malignancies. 21722812 2011
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 AlteredExpression group BEFREE We first identified potential transcriptionally important CpG sites using the methylation-specific oligonucleotide array in relation to mRNA expression of RASSF1A and BLU genes in primary lung tumors. 20877461 2010
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 AlteredExpression group LHGDN [Down-regulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1 and HYAL2 genes in non-small cell lung cancer]. 19140316 2009
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 Biomarker group CTD_human DNA methylation markers and early recurrence in stage I lung cancer. 18337602 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 PosttranslationalModification group LHGDN Critical role of deltaDNMT3B4/2 in regulating RASSF1A promoter-specific DNA methylation in non-small cell lung cancer. 19024105 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 GeneticVariation group LHGDN Putative association of the single nucleotide polymorphisms in RASSF1A promoter with Korean lung cancer. 18313166 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 PosttranslationalModification group LHGDN Promoter hypermethylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers. 17606310 2007
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 Biomarker group BEFREE In this study, we analyzed promoter methylation in the ras-association domain isoform A (RASSF1A) and the death-associated protein kinase (DAPK) genes in lung tumors from patients with primarily non-small cell lung cancer (NSCLC) from the Western Pennsylvania region. 17477876 2007
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 AlteredExpression group BEFREE H1299 lung cancer cells, lacking Fhit, Wwox, p16(INK4a) and Rassf1a expression due to epigenetic modifications, were used to assess efficacy of epigenetically targeted protocols in suppressing growth of lung tumors, by injection of 5-aza-2-deoxycytidine (AZA) and trichostatin A (TSA) in nude mice with established H1299 tumors. 17019711 2007
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 PosttranslationalModification group LHGDN Aberrant methylation of RASGRF2 and RASSF1A in human non-small cell lung cancer. 16596198 2006
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 PosttranslationalModification group LHGDN RASSF1A is not appropriate as an early detection marker or a prognostic marker for non-small cell lung cancer. 15700308 2005
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 AlteredExpression group LHGDN Involvement of the RASSF1A tumor suppressor gene in controlling cell migration. 16140931 2005
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 GeneticVariation group LHGDN Hypermethylation of RASSF1A and BLU tumor suppressor genes in non-small cell lung cancer: implications for tobacco smoking during adolescence. 15540210 2005
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 GeneticVariation group BEFREE The human Ras association domain family 1A gene (RASSF1A), recently cloned from the lung tumor locus at 3p21.3, was shown to be frequently inactivated by hypermethylation of its promoter region in a number of malignancies. 15711568 2005
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 Biomarker group LHGDN RASSF1A gene inactivation in non-small cell lung cancer and its clinical implication. 12794755 2003
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 PosttranslationalModification group BEFREE The newly identified 3p21.3 tumour suppressor gene RASSF1A is methylated in the majority of primary lung tumours, lung tumour cell lines and in a variable percentage of breast tumours. 12527916 2003
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 PosttranslationalModification group LHGDN The newly identified 3p21.3 tumour suppressor gene RASSF1A is methylated in the majority of primary lung tumours, lung tumour cell lines and in a variable percentage of breast tumours. 12527916 2003
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 PosttranslationalModification group BEFREE We found RASSF1A to be methylated in the majority of lung tumours, but to a lesser extent in breast and ovarian tumours. 12142046 2002
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 GeneticVariation group BEFREE The Ras association domain family 1 (RASSF1) gene cloned from the lung tumor suppressor locus 3p21.3 consists of two major alternative transcripts, RASSF1A and RASSF1C. 11429703 2001
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 Biomarker group BEFREE The human Ras association domain family 1A gene (RASSF1A), recently cloned from the lung tumor suppressor locus 3p21.3, was shown to be hypermethylated in primary lung tumors, and reexpression of RASSF1A suppressed the growth of lung cancer cells (R. Dammann et al., Nat.Genet., 25: 315-319, 2000). 11306494 2001
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.400 GeneticVariation group BEFREE In previous work, we cloned and identified the human RAS association domain family 1A gene (RASSF1A) from the lung tumor suppressor locus 3p21.3. 11668500 2001