Lung Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
RASSF1A deficiency profoundly enhanced the development of K-RAS-driven lung tumors <i>in vivo</i> Analysis of these tumors showed loss of RASSF1A-uncoupled RAS from the proapoptotic Hippo pathway as expected.
|
29735543 |
2018 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Using stable clones of two human lung tumor cell lines (NCI-H1792 and NCI-H1299) with shRNA-mediated silencing or ectopic overexpression of RASSF1A, we show that activated Rheb stimulates the Hippo pathway, but is suppressed in its ability to stimulate the TOR pathway.
|
27034171 |
2016 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Collectively, our results indicated that RASSF1 acts to restrict EMT and invasion by indirectly controlling YAP nuclear shuttling and activation through a RhoB-regulated cytoskeletal remodeling process, with potential implications to delay the progression of RASSF1-hypermethylated lung tumors.
|
26759237 |
2016 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
High percentage of lung tumor samples with simultaneous RASSF1A decreased expression and gene promoter methylation indicates its epigenetic silencing.
|
26112163 |
2015 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
RASSF1A, a candidate tumor suppressor gene, recently cloned from the lung tumor locus at 3p21.3, is frequently inactivated by hypermethylation of its promoter region in a number of malignancies.
|
21722812 |
2011 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We first identified potential transcriptionally important CpG sites using the methylation-specific oligonucleotide array in relation to mRNA expression of RASSF1A and BLU genes in primary lung tumors.
|
20877461 |
2010 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
[Down-regulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1 and HYAL2 genes in non-small cell lung cancer].
|
19140316 |
2009 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
DNA methylation markers and early recurrence in stage I lung cancer.
|
18337602 |
2008 |
Lung Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
LHGDN |
Critical role of deltaDNMT3B4/2 in regulating RASSF1A promoter-specific DNA methylation in non-small cell lung cancer.
|
19024105 |
2008 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Putative association of the single nucleotide polymorphisms in RASSF1A promoter with Korean lung cancer.
|
18313166 |
2008 |
Lung Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
LHGDN |
Promoter hypermethylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers.
|
17606310 |
2007 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
In this study, we analyzed promoter methylation in the ras-association domain isoform A (RASSF1A) and the death-associated protein kinase (DAPK) genes in lung tumors from patients with primarily non-small cell lung cancer (NSCLC) from the Western Pennsylvania region.
|
17477876 |
2007 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
H1299 lung cancer cells, lacking Fhit, Wwox, p16(INK4a) and Rassf1a expression due to epigenetic modifications, were used to assess efficacy of epigenetically targeted protocols in suppressing growth of lung tumors, by injection of 5-aza-2-deoxycytidine (AZA) and trichostatin A (TSA) in nude mice with established H1299 tumors.
|
17019711 |
2007 |
Lung Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
LHGDN |
Aberrant methylation of RASGRF2 and RASSF1A in human non-small cell lung cancer.
|
16596198 |
2006 |
Lung Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
LHGDN |
RASSF1A is not appropriate as an early detection marker or a prognostic marker for non-small cell lung cancer.
|
15700308 |
2005 |
Lung Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Involvement of the RASSF1A tumor suppressor gene in controlling cell migration.
|
16140931 |
2005 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Hypermethylation of RASSF1A and BLU tumor suppressor genes in non-small cell lung cancer: implications for tobacco smoking during adolescence.
|
15540210 |
2005 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The human Ras association domain family 1A gene (RASSF1A), recently cloned from the lung tumor locus at 3p21.3, was shown to be frequently inactivated by hypermethylation of its promoter region in a number of malignancies.
|
15711568 |
2005 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
RASSF1A gene inactivation in non-small cell lung cancer and its clinical implication.
|
12794755 |
2003 |
Lung Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
The newly identified 3p21.3 tumour suppressor gene RASSF1A is methylated in the majority of primary lung tumours, lung tumour cell lines and in a variable percentage of breast tumours.
|
12527916 |
2003 |
Lung Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
LHGDN |
The newly identified 3p21.3 tumour suppressor gene RASSF1A is methylated in the majority of primary lung tumours, lung tumour cell lines and in a variable percentage of breast tumours.
|
12527916 |
2003 |
Lung Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
We found RASSF1A to be methylated in the majority of lung tumours, but to a lesser extent in breast and ovarian tumours.
|
12142046 |
2002 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The Ras association domain family 1 (RASSF1) gene cloned from the lung tumor suppressor locus 3p21.3 consists of two major alternative transcripts, RASSF1A and RASSF1C.
|
11429703 |
2001 |
Lung Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The human Ras association domain family 1A gene (RASSF1A), recently cloned from the lung tumor suppressor locus 3p21.3, was shown to be hypermethylated in primary lung tumors, and reexpression of RASSF1A suppressed the growth of lung cancer cells (R. Dammann et al., Nat.Genet., 25: 315-319, 2000).
|
11306494 |
2001 |
Lung Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In previous work, we cloned and identified the human RAS association domain family 1A gene (RASSF1A) from the lung tumor suppressor locus 3p21.3.
|
11668500 |
2001 |