CHEK2, checkpoint kinase 2, 11200

N. diseases: 297; N. variants: 261
Disease: Lung Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.320 Biomarker group CTD_human Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. 24880342 2014
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.320 Biomarker group LHGDN Constitutional CHEK2 mutations are associated with a decreased risk of lung and laryngeal cancers. 18281249 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.320 AlteredExpression group BEFREE Moreover, and consistent with p14ARF being a determinant of CHK2 phosphorylation in lung carcinogenesis, a strong correlation between p14ARF and phospho-CHK2 (Thr68) protein expression is observed in human lung tumors (P < 0.00006). 16705183 2006