CHEK2, checkpoint kinase 2, 11200

N. diseases: 297; N. variants: 261
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.370 GeneticVariation group LHGDN Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer. 18571837 2008
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.370 GeneticVariation group BEFREE In this study, we have identified two novel somatic CHEK2 mutations, c.349A > G (p.R117G) and c.967A > C (p.E321K), in prostate tumor specimens and investigated the functions of these mutants in vivo. 16835864 2006
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.370 GeneticVariation group BEFREE We previously described 11 CHEK2 mutations in a group of 84 primary prostate tumors. 16941491 2006
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.370 GeneticVariation group LHGDN A large germline deletion in the Chek2 kinase gene is associated with an increased risk of prostate cancer. 17085682 2006
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.370 GeneticVariation group LHGDN We previously described 11 CHEK2 mutations in a group of 84 primary prostate tumors. 16941491 2006
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.370 GeneticVariation group LHGDN In this study, we have identified two novel somatic CHEK2 mutations, c.349A > G (p.R117G) and c.967A > C (p.E321K), in prostate tumor specimens and investigated the functions of these mutants in vivo. 16835864 2006
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.370 GeneticVariation group LHGDN A novel founder CHEK2 mutation is associated with increased prostate cancer risk. 15087378 2004
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.370 GeneticVariation group LHGDN Mutations in CHEK2 associated with prostate cancer risk. 12533788 2003
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.370 GeneticVariation group LHGDN CHEK2 variants associate with hereditary prostate cancer. 14612911 2003
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.370 Biomarker group CTD_human Mutations in CHEK2 associated with prostate cancer risk. 12533788 2003