|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
Nowadays CHK2 mutation is studied frequently in hereditary breast and ovarian cancer patients in addition to BRCA1/BRCA2.
|
31398194 |
2019 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
Mutation screening of TP53, CHEK2 and BRCA genes in patients at high risk for hereditary breast and ovarian cancer (HBOC) in Brazil.
|
30535581 |
2019 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Hereditary cancer screening: Case reports and review of literature on ten Ashkenazi Jewish founder mutations.
|
30152102 |
2018 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Prevalence of deleterious mutations among patients with breast cancer referred for multigene panel testing in a Romanian population.
|
29785153 |
2018 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Complexities of Variant Classification in Clinical Hereditary Cancer Genetic Testing.
|
28981386 |
2017 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Revisiting breast cancer patients who previously tested negative for BRCA mutations using a 12-gene panel.
|
27798748 |
2017 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Efforts Toward Consensus Variant Interpretation by Commercial Laboratories.
|
28135139 |
2017 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Multigene panels in Ashkenazi Jewish patients yield high rates of actionable mutations in multiple non-BRCA cancer-associated genes.
|
28495237 |
2017 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Genetic Predisposition to Breast Cancer Due to Mutations Other Than BRCA1 and BRCA2 Founder Alleles Among Ashkenazi Jewish Women.
|
28727877 |
2017 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Improving performance of multigene panels for genomic analysis of cancer predisposition.
|
26845104 |
2016 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Prioritizing Variants in Complete Hereditary Breast and Ovarian Cancer Genes in Patients Lacking Known BRCA Mutations.
|
26898890 |
2016 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
CausalMutation
|
disease |
CLINVAR |
Targeted massively parallel sequencing of a panel of putative breast cancer susceptibility genes in a large cohort of multiple-case breast and ovarian cancer families.
|
26534844 |
2016 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Conflicting Interpretation of Genetic Variants and Cancer Risk by Commercial Laboratories as Assessed by the Prospective Registry of Multiplex Testing.
|
27621404 |
2016 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
CausalMutation
|
disease |
CLINVAR |
Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.
|
26681312 |
2016 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
CausalMutation
|
disease |
CLINVAR |
Prevalence of mutations in a panel of breast cancer susceptibility genes in BRCA1/2-negative patients with early-onset breast cancer.
|
25503501 |
2015 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
CausalMutation
|
disease |
CLINVAR |
Use of panel tests in place of single gene tests in the cancer genetics clinic.
|
25318351 |
2015 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Prevalence of mutations in a panel of breast cancer susceptibility genes in BRCA1/2-negative patients with early-onset breast cancer.
|
25503501 |
2015 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we evaluated the presence and frequency of 1100delC and Del5395 mutations in CHEK2 gene in Serbian BRCA-negative HBOC cases.
|
24065469 |
2014 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
CausalMutation
|
disease |
CLINVAR |
Frequent germline deleterious mutations in DNA repair genes in familial prostate cancer cases are associated with advanced disease.
|
24556621 |
2014 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Panel-based testing for inherited colorectal cancer: a descriptive study of clinical testing performed by a US laboratory.
|
24506336 |
2014 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
CausalMutation
|
disease |
CLINVAR |
Utilization of multigene panels in hereditary cancer predisposition testing: analysis of more than 2,000 patients.
|
24763289 |
2014 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
Constitutional CHEK2 mutations are infrequent in early-onset and familial breast/ovarian cancer patients from Pakistan.
|
23806170 |
2013 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Response to DNA damage of CHEK2 missense mutations in familial breast cancer.
|
22419737 |
2012 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
ORPHANET |
Two new CHEK2 germ-line variants detected in breast cancer/sarcoma families negative for BRCA1, BRCA2, and TP53 gene mutations.
|
21562711 |
2011 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
CausalMutation
|
disease |
CLINVAR |
Rare, evolutionarily unlikely missense substitutions in CHEK2 contribute to breast cancer susceptibility: results from a breast cancer family registry case-control mutation-screening study.
|
21244692 |
2011 |