|
HIV Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Using an appropriate combination of C65690M and ANT-152 p24 antibodies capable of detecting all HIV types and highly sensitive TRF-based europium nano particle assay platform, we developed a sensitive p24 antigen assay that can detect HIV infection of all HIV subtypes and may be useful in early detection.
|
30411969 |
2019 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Since its introduction in the US, studies have shown that the Determine HIV-1/2 Ag/Ab Combo assay (Determine Ag/Ab) detects HIV infection earlier than laboratory-based IgM/IgG-sensitive IAs, but its sensitivity for HIV-1 p24 Ag detection is reduced compared to laboratory-based Ag/Ab assays.
|
29803089 |
2018 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
The overall sensitivity of the test for diagnosing HIV infection based on detection of p24 antigen and/or antibodies was 92% (95% CI 86% to 98%) (82/89).
|
28062734 |
2018 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Using RNA fluorescence in situ hybridization, CD32 coexpression with HIV RNA or p24 was detected after in vitro HIV infection (peripheral blood mononuclear cell and tissue) and in vivo within lymph node tissue from HIV-infected individuals.
|
29669853 |
2018 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
More and more countries test for HIV infection using combination assays that simultaneously detect p24 antigen and HIV antibodies.
|
29020658 |
2017 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Methods Retrospective review of medical records of adult patients newly diagnosed with HIV infection (reactive immunoassay for antibodies to HIV-1/HIV-2 or HIV p24 antigen) in the Dermatology and Venereology Department of a Portuguese central hospital in the period between January 2005 and December 2013.
|
27815548 |
2017 |
|
HIV Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Plasma viral load, p24 levels and CD4(+) T cells were measured as markers of productive HIV infection.
|
27241024 |
2016 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Because IFN-gamma enhances IgG2 production, and IgG2 antibodies to HIV antigens and the 'high-affinity' polymorphism of FcgammaRIIa (the major Fc receptor for IgG2) have been associated with a favourable outcome of HIV infection, we examined the association of IgG2 antibodies to HIV p24 and 'high-affinity' polymorphisms of FcgammaRIIa with control of HIV replication in these patients.
|
20634666 |
2010 |
|
HIV Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We demonstrate that loss of ITK function resulted in marked reductions in intracellular p24 levels upon HIV infection.
|
18443296 |
2008 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Placentas and fetal organs were examined by routine light microscopy, immunostaining for p24 capsid protein, and in situ PCR to localize which cells were infected with HIV-1 subtype E. The number of previous abortions was not a factor in placental HIV infection since this number was higher in seronegative women (P < 0.01).
|
15846390 |
2005 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
An immunological explanation for the protective role for HLA B27 in HIV disease is that B27+ patients have a specific and strong CTL response against the p24 epitope, a conservative HIV protein that does not easily mutate.
|
15332431 |
2004 |
|
HIV Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The authors present evidence that in diseased tissues showing a high level of HIV DNA and macrophage-associated HIV p24 antigen expression from end stage forms of HIV disease, HIV-1 integration sites were favored within genes and transcriptionally active host cell genomic loci.
|
12843741 |
2003 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Testing for the p24 antigen of the human immunodeficiency virus (HIV) may detect early HIV infection in the seronegative window; however, falsely reactive results may occur in cadaver specimens.
|
11322416 |
2001 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Testing of several HIV-1 seroconversion panels has demonstrated that the HIV-1/2 qualitative RNA assay detects HIV infection on the average of 6 days before p24 antigen can be detected and 11 days before antibodies can be detected.
|
10655373 |
2000 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Given that initial HIV infection of an individual instigates abundant HIV replication from inception until death, and that the life of infected T-cells is only several days, the administration of AZT should lead both in vitro and in vivo (i) to decreased formation of proviral DNA; and thus (ii) to decreased frequencies of 'HIV isolation' (detection of p24 or reverse transcription or both) in stimulated cultures/cocultures of T-cells from seropositive individuals; (iii) to decreased synthesis of HIV p24 and RNA ('antigenaemia', 'plasma viraemia', 'viral load') ultimately resulting in low or absent levels of all three parameters; and (iv) to a perfect and direct correlation between all these parameters.
|
11594171 |
1999 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
The Enzymun-Test HIV Combi permits an earlier diagnosis of HIV infection than third generation assays through the detection of p24 antigen, which may be present in serum samples from individuals with recent HIV infection prior to seroconversion and it shows an excellent sensitivity for antibodies to all known HIV-1 subtypes and HIV-2.
|
9820572 |
1998 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
T67 cells were susceptible to both HIVLai and MTB infections, and MTB was able to increase HIV infection in T67 cells, as demonstrated by a marked increase in p24 release.
|
9223073 |
1997 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Measurement of p24 antigen in serum was, in contrast, a less sensitive marker of HIV infection: only 5/13 infants had positive p24 antigen results.
|
9240857 |
1997 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
This approach may be used to confirm true status of the HIV infection when p24 results are negative or HIV RNAs in serum/plasma are below the threshold of detection.
|
9179766 |
1997 |
|
HIV Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Variation in plasma RNA levels, CD4 cell counts, and p24 antigen levels in clinically stable men with human immunodeficiency virus infection.
|
8655993 |
1996 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
To investigate the association of human immunodeficiency virus (HIV) with various DNA viruses, including hepatitis B virus (HBV), cytomegalovirus (CMV) and Epstein-Barr virus, (EBV), simultaneous detection of HIV p24 antigen, HBV surface antigen and DNA, CMV-DNA and EBV-DNA expression was performed in phytohemagglutinin-stimulated peripheral blood mononuclear (PBMC) culture supernatants obtained from 54 individuals at risk for HIV infection.
|
7588843 |
1995 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Immune complex formation causes underdetection of p24 antigen in human immunodeficiency virus (HIV) infection.
|
8035017 |
1994 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Assay of human vitreous specimens obtained postmortem for HIV antibodies, or HIV p24 antigen, is reported to be a reliable technique to demonstrate HIV infection in possible cornea donors from whom serum could not be obtained.
|
8407115 |
1993 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
HIV infection was shown by polymerase chain reaction (PCR) detection of proviral sequences (gag and pol genes), by p24 antigen synthesis, and by cocultivation assay with MT2 cells.
|
8461467 |
1993 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Statistical analysis showed a concordance between HIV infection and in vitro detection of EBV DNA (P < 0.002); particularly, a strong correlation between the presence of EBV DNA and p24 in culture was observed (P < 0.001).
|
1335543 |
1992 |