CHP1, calcineurin like EF-hand protein 1, 11261

N. diseases: 141; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0042749
Disease: Viremia
Viremia
0.030 Biomarker disease BEFREE CTL were associated with control of viraemia when combined with p24 proliferative responses. 19077215 2008
CUI: C0042749
Disease: Viremia
Viremia
0.030 AlteredExpression disease BEFREE Given that initial HIV infection of an individual instigates abundant HIV replication from inception until death, and that the life of infected T-cells is only several days, the administration of AZT should lead both in vitro and in vivo (i) to decreased formation of proviral DNA; and thus (ii) to decreased frequencies of 'HIV isolation' (detection of p24 or reverse transcription or both) in stimulated cultures/cocultures of T-cells from seropositive individuals; (iii) to decreased synthesis of HIV p24 and RNA ('antigenaemia', 'plasma viraemia', 'viral load') ultimately resulting in low or absent levels of all three parameters; and (iv) to a perfect and direct correlation between all these parameters. 11594171 1999
CUI: C0042749
Disease: Viremia
Viremia
0.030 Biomarker disease BEFREE The critical endpoint of the study was the influence of key baseline characteristics (CD4 cell counts, clinical stage, HIV-1 p24 antigen, virus phenotype and viraemia) upon the time to development of mutation at codon 215. 11322281 1997