Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
|
29844566 |
2018 |
Acute infectious disease
|
0.020 |
Biomarker
|
group |
BEFREE |
We used mice deficient in all three immunoproteasome subunits (triple-knockout [TKO] mice) to determine whether immunoproteasome activity is essential for control of MAV-1 replication or inflammatory responses to acute infection.
|
31092582 |
2019 |
Pneumonia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Histological evidence of pulmonary inflammation was similar in B6 and lpr mice, but lung mRNA levels and airway proinflammatory cytokine concentrations were lower in MAV-1-infected lpr mice compared to infected B6 mice.
|
29908447 |
2018 |
Respiratory Tract Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
FasL and Fas expression were increased in the lungs of C57BL/6 (B6) mice during MAV-1 respiratory infection.
|
29908447 |
2018 |
Acute infectious disease
|
0.020 |
AlteredExpression
|
group |
BEFREE |
We detected MAV-1 in adipose tissue during acute MAV-1 infection, but we did not detect virus-induced increases in adipose tissue cytokine expression or histological evidence of adipose tissue inflammation during acute infection.
|
29141203 |
2018 |
Pneumonitis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Histological evidence of pulmonary inflammation was similar in B6 and lpr mice, but lung mRNA levels and airway proinflammatory cytokine concentrations were lower in MAV-1-infected lpr mice compared to infected B6 mice.
|
29908447 |
2018 |
Encephalitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The findings highlight the complex nature of encephalitis and suggests that IL-1 has a protective effect for the development of MAV-1-induced encephalitis.
|
27903802 |
2017 |
Encephalitis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that increased MMP activity in the brains of MAV-1-infected susceptible mice may be due to MMP activity produced by endothelial cells, astrocytes, and microglia, which in turn may contribute to BBB disruption and encephalitis in susceptible mice.<b>IMPORTANCE</b> RNA and DNA viruses can cause encephalitis; in some cases, this is accompanied by MMP-mediated disruption of the BBB.
|
28053109 |
2017 |
Pneumonia
|
0.020 |
Biomarker
|
disease |
BEFREE |
CD8 T cells promote MAV-1-induced pulmonary inflammation via a mechanism that is independent of direct antiviral effects.
|
28410483 |
2017 |
Respiratory Tract Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
We used mouse adenovirus type 1 (MAV-1) to define CD8 T cell contributions to the pathogenesis of adenovirus respiratory infection.
|
28410483 |
2017 |
myeloblastosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Myeloblastosis-associated virus 2 (MAV-2) is a highly tumorigenic simple avian retrovirus.
|
28768863 |
2017 |
Pneumonitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
CD8 T cells promote MAV-1-induced pulmonary inflammation via a mechanism that is independent of direct antiviral effects.
|
28410483 |
2017 |
myeloblastosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The molecularly cloned myeloblastosis-associated virus type-1(N) (MAV-1(N)) strain induces specifically nephroblastomas in chicken.
|
14599793 |
2003 |
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data indicate that MAV-1 is not associated with obesity in infected mice.
|
29141203 |
2018 |
Liver neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Here we report the results of molecular analyses of MAV-2-induced liver tumors that fall into three classes: hepatic hemangiosarcomas (HHSs), intrahepatic cholangiocarcinomas (ICCs), and hepatocellular carcinomas (HCCs).
|
28768863 |
2017 |
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The structures of truncated <i>EGFR</i> and <i>RON</i> closely mimic the structures of oncogenic variants of these genes frequently found in human tumors (<i>EGFRvIII</i> and <i>sfRON</i>).<b>IMPORTANCE</b> These data describe the mechanisms of oncogenesis induced in chickens by the MAV-2 retrovirus.
|
28768863 |
2017 |
Viral Encephalitis
|
0.010 |
Biomarker
|
group |
BEFREE |
MAV-1 produces viral encephalitis in its natural host, providing a good model for studying factors involved in encephalitis development.
|
27903802 |
2017 |
Intrahepatic Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we report the results of molecular analyses of MAV-2-induced liver tumors that fall into three classes: hepatic hemangiosarcomas (HHSs), intrahepatic cholangiocarcinomas (ICCs), and hepatocellular carcinomas (HCCs).
|
28768863 |
2017 |
Pseudohypoaldosteronism, Type II
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mutations in KLHL2 have not been reported in patients with PHAII, suggesting that KLHL2 plays a different physiological role than that played by KLHL3 in the kidney.
|
28414128 |
2017 |
NEUROTICISM
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The temporal expression analysis revealed that the neuroticism-associated genes were divided into three expression patterns: KLHL2, CELF4 and CRHR1 were preferentially expressed during postnatal stages; PTPRD, ELAVL2 and MFHAS1 were expressed during prenatal stages; and the other three genes were not expressed during specific life stages.
|
28433457 |
2017 |
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we report the results of molecular analyses of MAV-2-induced liver tumors that fall into three classes: hepatic hemangiosarcomas (HHSs), intrahepatic cholangiocarcinomas (ICCs), and hepatocellular carcinomas (HCCs).
|
28768863 |
2017 |
Hyperkalemic Mineralocorticoid Resistance
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mutations in KLHL2 have not been reported in patients with PHAII, suggesting that KLHL2 plays a different physiological role than that played by KLHL3 in the kidney.
|
28414128 |
2017 |
Tuberculosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
MAV_2450, a polyketide synthase homologue to Mycobacterium tuberculosis pks12, was identified.
|
19745033 |
2010 |
Nephroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results obtained indicated that deletions of the LTRs resulted in a modification of the pathogenic spectrum of MAV-1(N) and a decreased efficiency for nephroblastoma induction.
|
14599793 |
2003 |