|
Schizophrenia
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
For example, an elegant roadmap was laid out a year ago by Karolina Kauppi and colleagues wherein they combined a data set for schizophrenia risk genes and another set of genes associated with antipsychotic drug targets.<sup>3</sup> Using this "network biology" approach, they identified four schizophrenia risk genes that were also antipsychotic drug targets (GRM3, DRD2, CHRM4, and CYP2D6); they also found several molecular targets that are not currently connected to antipsychotic drug treatment, providing researchers with some potential targets for novel therapeutics.<sup>4</sup>.
|
31340894 |
2019 |
|
Schizophrenia
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
RNA-sequencing analyses of cortical and striatal micropunches from Brd1<sup>+/-</sup> and wild-type mice revealed differential expression of genes enriched for schizophrenia risk, including several schizophrenia genome-wide association study risk genes (e.g., calcium channel subunits [Cacna1c and Cacnb2], cholinergic muscarinic receptor 4 [Chrm4)], dopamine receptor D<sub>2</sub> [Drd2], and transcription factor 4 [Tcf4]).
|
27837920 |
2017 |
|
Schizophrenia
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
CHRM4 is located in a region of strong linkage disequilibrium on chromosome 11 that includes genes associated with schizophrenia.
|
27269905 |
2016 |
|
Schizophrenia
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
These findings led us to determine whether variation in the CHRM4 gene sequence was associated with an altered risk of schizophrenia by sequencing the CHRM4 gene from the brains of 76 people with the disorder and 74 people with no history of psychiatric disorders.
|
23490763 |
2013 |
|
Schizophrenia
|
0.360 |
Biomarker
|
disease |
PSYGENET |
These findings led us to determine whether variation in the CHRM4 gene sequence was associated with an altered risk of schizophrenia by sequencing the CHRM4 gene from the brains of 76 people with the disorder and 74 people with no history of psychiatric disorders.
|
23490763 |
2013 |
|
Schizophrenia
|
0.360 |
Biomarker
|
disease |
PSYGENET |
Genetic variation in a region on chromosome 11 that contains the candidate genes AMBRA1, DGKZ, CHRM4 and MDK was significantly associated with SCZ in the combined sample (n=11 540; P=3.89 × 10(-9), odds ratio (OR)=1.25).
|
21747397 |
2012 |
|
Schizophrenia
|
0.360 |
Biomarker
|
disease |
BEFREE |
Genetic variation in a region on chromosome 11 that contains the candidate genes AMBRA1, DGKZ, CHRM4 and MDK was significantly associated with SCZ in the combined sample (n=11 540; P=3.89 × 10(-9), odds ratio (OR)=1.25).
|
21747397 |
2012 |
|
Schizophrenia
|
0.360 |
AlteredExpression
|
disease |
LHGDN |
To test the hypothesis that muscarinic receptors are involved in the pathology of schizophrenia, we measured muscarinic(1) (M1R) and muscarinic(4)(M4R) protein and mRNA as well as [(3)H]pirenzepine binding in Brodmann's areas (BA) 9 and 40 obtained postmortem from 20 schizophrenic and 20 age/sex-matched control subjects.
|
12476323 |
2002 |
|
Schizophrenia
|
0.360 |
Biomarker
|
disease |
BEFREE |
To test the hypothesis that muscarinic receptors are involved in the pathology of schizophrenia, we measured muscarinic(1) (M1R) and muscarinic(4)(M4R) protein and mRNA as well as [(3)H]pirenzepine binding in Brodmann's areas (BA) 9 and 40 obtained postmortem from 20 schizophrenic and 20 age/sex-matched control subjects.
|
12476323 |
2002 |