Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.040 Biomarker group BEFREE Finally, combined treatment with LKB1 and FUS1 prolonged overall survival in lung tumor-bearing mice. 24659339 2014
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.040 Biomarker group BEFREE These findings support the concept that FUS1 gene and Fus1 protein abnormalities could be used to develop new strategies for molecular cancer therapy for a significant subset of lung tumors. 18172250 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.040 Biomarker group BEFREE Intratumoral administration of FUS1 gene complexed to DOTAP:cholesterol (DOTAP:Chol) liposome into subcutaneous H1299 and A549 lung tumor xenograft resulted in significant (P = .02) inhibition of tumor growth. 15486560 2004
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.040 AlteredExpression group LHGDN A myristoylation-deficient mutant of the Fus1 protein abrogated its ability to inhibit tumor cell-induced clonogenicity in vitro, to induce apoptosis in lung tumor cells, and to suppress the growth of tumor xenografts and lung metastases in vivo and rendered it susceptible to rapid proteasome-dependent degradation. 15126327 2004