|
Schizophrenia
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
Our results show that rs16969968 on CHRNA5 is tightly linked to genetic susceptibility, psychotic symptoms and cognitive deficits in SCZ in an early-onset Chinese population, suggesting that CHRNA5 may play an important role in the etiology of SCZ.
|
30366711 |
2019 |
|
Schizophrenia
|
0.480 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that genome-wide variants shared between smoking quantity and schizophrenia contribute to a common pathophysiology underlying these traits involving altered CHRNA5 expression in the brain.
|
30202994 |
2019 |
|
Schizophrenia
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
This study is to explore the potential association between CHRNA5 (OMIM#118505) polymorphisms and schizophrenia susceptibility in a Chinese population.
|
31342675 |
2019 |
|
Schizophrenia
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
One cis-eQTL, rs16969968, results in a functionally disruptive missense mutation in CHRNA5, a schizophrenia-implicated gene.
|
30142156 |
2018 |
|
Schizophrenia
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
In addition, heaviness of smoking (proxied by a variant in the CHRNA5-A3-B4 gene cluster) and risk of depression and schizophrenia have been investigated, with no evidence of a causal effect of smoking on depression but some evidence of a causal effect on schizophrenia.
|
28921935 |
2018 |
|
Schizophrenia
|
0.480 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.
|
28540026 |
2017 |
|
Schizophrenia
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
Recently, genome-wide association studies (GWAS) identified single-nucleotide polymorphisms (SNPs) in the human CHRNA5 gene, encoding the α5 nAChR subunit, that increase the risks for both smoking and schizophrenia.
|
28112735 |
2017 |
|
Schizophrenia
|
0.480 |
Biomarker
|
disease |
PSYGENET |
Variants in the 15q25 gene cluster are associated with risk for schizophrenia/bipolar illness, negative symptoms of schizophrenia, and influence CHRNA5 expression in the brain and peripheral blood mononuclear cells.
|
23196875 |
2013 |
|
Schizophrenia
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
Variants in the 15q25 gene cluster are associated with risk for schizophrenia/bipolar illness, negative symptoms of schizophrenia, and influence CHRNA5 expression in the brain and peripheral blood mononuclear cells.
|
23196875 |
2013 |
|
Schizophrenia
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
A CHRNA5 allele related to nicotine addiction and schizophrenia.
|
21418140 |
2011 |
|
Schizophrenia
|
0.480 |
Biomarker
|
disease |
PSYGENET |
A CHRNA5 allele related to nicotine addiction and schizophrenia.
|
21418140 |
2011 |