Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0040332
Disease: Tobacco Dependence
Tobacco Dependence
0.330 Biomarker disease CTD_human The Value of Biosamples in Smoking Cessation Trials: A Review of Genetic, Metabolomic, and Epigenetic Findings. 28472521 2018
CUI: C0040332
Disease: Tobacco Dependence
Tobacco Dependence
0.330 Biomarker disease BEFREE SNPs within CHRNA5-A3-B4 and CYP2A6/B6 are associated with smoking dependence but not with tobacco dependence treatment outcomes in the Czech population. 28069549 2017
CUI: C0040332
Disease: Tobacco Dependence
Tobacco Dependence
0.330 GeneticVariation disease BEFREE Indeed, genetic variation in the CHRNA5-CHRNA3-CHRNB4 gene cluster, encoding the α5, α3, and β4 nAChR subunits, respectively, has been shown to increase vulnerability to tobacco dependence and smoking-associated diseases including lung cancer. 23143843 2013
CUI: C0040332
Disease: Tobacco Dependence
Tobacco Dependence
0.330 GeneticVariation disease BEFREE Recent human genetic studies also imply that tobacco dependence is affected by polymorphisms in the alpha3/alpha5 subunits of the nAChR (CHRNA3/CHRNA5) gene cluster. 20393456 2010
CUI: C0040332
Disease: Tobacco Dependence
Tobacco Dependence
0.330 Biomarker disease CTD_human Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. 18414406 2009
CUI: C0040332
Disease: Tobacco Dependence
Tobacco Dependence
0.330 Biomarker disease CTD_human A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence. 18519132 2008