APOA5, apolipoprotein A5, 116519

N. diseases: 107; N. variants: 22
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE Apolipoprotein A5 (ApoA5) has been shown to influence the prevalence and pathology of obesity. 31560287 2020
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE APOA5 genotype (TC + CC), age, and obesity could be used as prognostic risk factors for a very severe stroke (NIHSS ≥ 21). 31327072 2019
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE In this review, we focus on the association of gene and protein of apoA5 with obesity and metabolic syndrome, and provide new insights into the physiological role of apoA5 in humans, giving a potential therapeutic target for obesity and associated disorders. 30053818 2018
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE The results revealed that methylation levels within HDAC4 and RAX2 loci were positively associated with obesity, while the methylation levels of loci within APOA5 and CES1 loci were negatively correlated with obesity. 29797594 2018
CUI: C0028754
Disease: Obesity
Obesity
0.100 Biomarker disease BEFREE The results of the present study suggested that apoA5 may serve as a potential therapeutic target for the treatment of obesity and its related disorders. 28901468 2017
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE Our data clearly show that the Arg282Ser mutation in APOA5 gene determines a reduction of TG, total and LDL-cholesterol and apolipoprotein A-V levels in overweight/obese children and adolescents, demonstrating that this mutation has the power to affect lipid levels already since childhood. 28927406 2017
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE These results support a potential role for APOA5 common variants and related haplotypes as risk factors for obesity. 26524954 2015
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE Our results suggest that dietary fat intake modifies the effect of APOA5 and LEPR polymorphisms on serum triglycerides, cholesterol levels and obesity in young subjects. 26365669 2015
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE Triglyceride-raising APOA5 genetic variants are associated with obesity and non-HDL-C in Chinese children and adolescents. 24903888 2014
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE The contributions of APOA5-1131CC homozygotes to obesity risk in those who consume higher TEI were all significantly high regardless of percentage of energy intake from dietary macronutrients. 25263629 2014
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE In current study two SNPs rs662799 risk allele G (P = 0.03) and rs3135506 risk allele C (P = 0.05) of APOA5 were found to be associated with significant higher risk of triglyceride levels, irrespective of age, sex, obesity, diabetes, hypertension and smoking. 24402875 2014
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE Population studies conducted in various countries have demonstrated an association between single nucleotide polymorphisms (SNPs) in ApoA5 and the increased risk to cardiovascular disease and metabolic syndrome (including diabetes and obesity). 23000317 2013
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE In conclusion, we have replicated previous gene-diet interactions between APOA5 -1131T > C SNP and fat intake for obesity traits and detected a novel interaction for TG-rich lipoprotein concentrations. 21209257 2011
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE In summary, we identified significant interactions for APOA5 S19W and LPL m107 for obesity in Caribbean Hispanics. 19629056 2010
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE A triglyceride-raising APOA5 genetic variant is negatively associated with obesity and BMI in the Chinese population. 20134407 2010
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE In multivariate regression models, the c56C > G SNP, plasma apoCIII, plasma nonesterified fatty acids, hepatic APOA5 transcripts, sex and a weak association with obesity status explained 61% of the variance in apoAV plasma levels. 18537870 2008
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE We found that: (i) genotypes, including those of APOA5 S19W, APOA5 -1131T > C, APOE, GCKR, TRIB1 and TBL2/MLXIPL, were significantly associated with severe HTG; (ii) odds ratios for these genetic variables were significant in both univariate and multivariate regression analyses, irrespective of the presence or absence of diabetes or obesity; (iii) a significant fraction-about one-quarter-of the explained variation in disease status was associated with these genotypes. 18596051 2008
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation disease BEFREE APOA5-1131C minor allele carriers had a lower obesity risk (OR, 0.61, 95%; CI, 0.39-0.98; P = 0.032) and overweight risk (OR, 0.63, 95%; CI, 0.41-0.96; P = 0.031) compared with TT subjects in the high fat intake group (>or=30% of energy ) but not when fat intake was low (OR, 1.16, 95%; CI, 0.77-1.74; P = 0.47 and OR = 1.15, 95%; CI, 0.77-1.71; P = 0.48) for obesity and overweight, respectively). 17211608 2007