Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
CTD_human |
|
|
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression.
|
19590397 |
2009 |
Major Depressive Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide.
|
16192985 |
2006 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
TPH2 rs4290270 was genotyped in 165 suicide attempters and 188 suicide non-attempters diagnosed with major depressive disorder, bipolar disorder and schizophrenia.
|
28084537 |
2017 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Tryptophan hydroxylase-2 polymorphism is associated with white matter integrity in first-episode, medication-naïve major depressive disorder patients.
|
30822678 |
2019 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
A rare mutation in tryptophan hydroxylase 2 (Tph2), the rate limiting enzyme for 5-HT synthesis, was identified in several patients with major depression, and knock-in mice expressing the analogous mutation (R439H Tph2 KI) show 80% reduction in 5-HT synthesis and tissue levels.
|
23336047 |
2013 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Accumulating evidences suggest that Tryptophan hydroxylase 2 (TPH2) gene is associated with major depressive disorder (MDD) and cognitive function.
|
26057341 |
2015 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Accumulating evidences suggest that Tryptophan hydroxylase 2 (TPH2) gene is associated with major depressive disorder (MDD) and cognitive function.
|
26057341 |
2015 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (Tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major depressive disorder, the circuit level alterations that results from serotonergic hypofunction remain poorly understood.
|
23467366 |
2013 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (Tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major depressive disorder, the circuit level alterations that results from serotonergic hypofunction remain poorly understood.
|
23467366 |
2013 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although the sample size is small, results from this study suggest that the TPH2 C2755A polymorphism may represent a population-specific risk factor for peripartum major depression and anxiety disorder, perhaps by interacting with hormones.
|
19588223 |
2009 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, an increased frequency of G allele of TPH2 SNP may be associated with elevated suicidal behavior itself rather than with the diagnosis of major depression and may increase risk of suicidality, independent of diagnosis.
|
19162119 |
2009 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Gene-disease association studies have reported a relationship between TPH2 and major depressive disorder (MDD) in different populations, however subsequent studies have produced contradictory results.
|
22693556 |
2012 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations in the TPH2 gene have been associated with an increased risk for major depression and suicidal behavior.
|
17251907 |
2007 |
Major Depressive Disorder
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
In conclusion, the present study demonstrated that TPH2 expression was regulated by DNA methylation of the TPH2 promoter region in patients with MDD.
|
25955598 |
2015 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we aimed to investigate the association of tryptophan hydroxylase 2 gene with MDD and its treatment response in the Chinese Han population.
|
21620479 |
2011 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In total, 14 single nucleotide polymorphisms (SNPs) in coding regions of 10 serotonergic genes (HTR1A, HTR1B, HTR1D, HTR2A, HTR3A, HTR3C, HTR3D, HTR3E, HTR5A and TPH2) were genotyped in 308 Chinese Han patients with major depressive disorder.
|
21937687 |
2012 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression.
|
15629698 |
2005 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Markers in TPH2 have been implicated in suicide and major depressive disorder, but the results across studies are inconsistent.
|
16806105 |
2007 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
One hundred and thirteen patients with MDD and eighty-six healthy controls underwent T1-weighted structural magnetic resonance imaging and genotyping for TPH2 rs4570625.
|
27807918 |
2017 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings provide evidence for an involvement of genetic variants of the TPH2 gene in the pathogenesis of MD and might be a hint on the repeatedly discussed duality of the serotonergic system.
|
15124006 |
2004 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings show that TPH2 genetic variants may play a role in MDD susceptibility and in acute therapeutic response to selective serotonin reuptake inhibitors.
|
19272410 |
2009 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that TPH2 variants neither have a major role in MD, BD and schizophrenia nor in response to treatments.
|
21396719 |
2011 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Polymorphisms in the gene encoding the serotonin synthesis enzyme Tph2 have been identified in mental illnesses, including bipolar disorder, major depression, autism, schizophrenia, and ADHD.
|
24196946 |
2014 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Single locus analysis in pooled and ethnically stratified subjects revealed no association between each of the three variants of the TPH2 gene with susceptibility to MDD.
|
24376086 |
2015 |