TPH2, tryptophan hydroxylase 2, 121278

N. diseases: 137; N. variants: 37
Disease: Anorexia Nervosa ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		0.040 GeneticVariation disease BEFREE Following on from previous work by our group where we showed that early onset anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) shared a common genetic background, the aim of the present study is to assess genetic pleiotropy related to the serotonergic system (SLC6A4, 5HTR2A, 5HTR2C, TPH2, SLC18A1), in a common phenotype such as very-early age of onset. 30554102 2019
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		0.040 GeneticVariation disease BEFREE In addition, rs3825885 (NTRK3, p = 9 × 10(-4)) was identified as an AN risk variant, and rs11179027 (TPH2, p = 2 × 10(-3)) as an OCD marker. 23337130 2013
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		0.040 GeneticVariation disease BEFREE TPH2 (tryptophan hydroxylase 2) SNP rs1473473 was previously associated with anorexia nervosa and EDs characterized by SV. 23239044 2013
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		0.040 GeneticVariation disease BEFREE The meta-analysis revealed that the tryptophan hydroxylase 2 polymorphism rs1473473 was associated with a higher risk for AN, EDs characterized by SV and for the combined group. 20946355 2011