Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE TPH2 gene polymorphisms and bipolar disorder: A meta-analysis. 26365518 2016
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 Biomarker disease PSYGENET Our results indicate that in the Han Chinese population TPH2 may be a potential susceptibility gene for bipolar disorder. 25152196 2015
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE Association study of TPH2 polymorphisms and bipolar disorder in the Han Chinese population. 25152196 2015
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE Polymorphisms in the gene encoding the serotonin synthesis enzyme Tph2 have been identified in mental illnesses, including bipolar disorder, major depression, autism, schizophrenia, and ADHD. 24196946 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 Biomarker disease PSYGENET Polymorphisms in the gene encoding the serotonin synthesis enzyme Tph2 have been identified in mental illnesses, including bipolar disorder, major depression, autism, schizophrenia, and ADHD. 24196946 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 Biomarker disease PSYGENET The aim of this study is to investigate a possible association between TPH2 gene polymorphisms and the PD comorbidity susceptibility.Our sample consisted of 515 patients; 274 patients with BD (subtypes I and II), including 45 patients with lifetime panic disorder comorbidity and 241 controls. 21085052 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE Association study of tryptophan hydroxylase 2 gene polymorphisms in bipolar disorder patients with panic disorder comorbidity. 21085052 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 Biomarker disease PSYGENET Our results suggest that TPH2 variants neither have a major role in MD, BD and schizophrenia nor in response to treatments. 21396719 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 Biomarker disease PSYGENET We analyzed 62 genotyped variants within the selected genes (BDNF, NTRK2, SLC6A4, TPH2, P2RX7, DAOA, COMT, DISC1, and MAOA) against the presence of mood disorder, and in post-hoc analyses, specifically against bipolar disorder or major depressive disorder. 21438144 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE The present study is aimed at exploring whether some single nucleotide polymorphisms (SNPs) within the tryptophan hydroxylase 2 gene (TPH2) could be associated with major depression (MD), bipolar disorder (BD) and schizophrenia and whether they could predict clinical outcomes in Korean in-patients treated with antidepressants, mood stabilizers and antipsychotics, respectively. 21396719 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE Association of polymorphisms of the tryptophan hydroxylase 2 gene with risk for bipolar disorder or suicidal behavior. 19800079 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 Biomarker disease BEFREE Support for tryptophan hydroxylase-2 as a susceptibility gene for bipolar affective disorder. 19352219 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease LHGDN SNPs located in a haplotype block covering the 5'region of the gene as well as a rare, non-synonymous SNP, resulting in a Pro206Ser substitution, showed significant association with bipolar disorder. 17905754 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder. 17905754 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE The TPH2 might contribute to the risk of both BPAD and SA in families with BPAD. 16806105 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE Association of functional polymorphisms of the human tryptophan hydroxylase 2 gene with risk for bipolar disorder in Han Chinese. 17768266 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE Polymorphisms in the neuronal isoform of tryptophan hydroxylase 2 are associated with bipolar disorder in French Canadian pedigrees. 17167340 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease LHGDN Case-control studies support the presence of a susceptibility locus for bipolar disorder in tryptophan hydroxylase 2. 17167340 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE TPH2 genotypes were determined in 69 subjects with a diagnosis of schizophrenia or bipolar disorder, among which 22 died by suicide. 16436194 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 Biomarker disease BEFREE Association of brain-specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population. 17015812 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease BEFREE Tryptophan hydroxylase 2 gene expression and promoter polymorphisms in bipolar disorder and schizophrenia. 16240163 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 Biomarker disease BEFREE With respect to TPH1 and TPH2, the majority of studies did not provide evidence for an association between these genes and bipolar disorder. 15727488 2005