TPH2, tryptophan hydroxylase 2, 121278

N. diseases: 137; N. variants: 37
Disease: Borderline Personality Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder 		0.040 GeneticVariation disease BEFREE The aim of this study was to examine the association between the polymorphisms in TPH2 and BPD. 25152196 2015
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder 		0.040 GeneticVariation disease BEFREE We found an association between the previously described TPH2 "risk" haplotype and BPD diagnosis, affective lability, suicidal/parasuicidal behavior, and aggression scores. 20451217 2010
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder 		0.040 Biomarker disease BEFREE We also detected significant interactions between 5-HT2C and TPH2 (p=0.001), and among 5-HT2C, 5-HTT, MAOA and TPH2 (p=0.001) in BPD. 19032968 2009
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder 		0.040 GeneticVariation disease BEFREE In addition, allelic alteration of polymorphisms in the promoter region and exon 2 of TPH2 caused noteworthy functional losses in promoter and enzyme activities, respectively, indicating the potential susceptibility loci for BPD. 17768266 2007