TPH2, tryptophan hydroxylase 2, 121278

N. diseases: 137; N. variants: 37
Disease: Depressive Symptoms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms 		0.060 GeneticVariation phenotype BEFREE To investigate the relationship between exonic variant (rs4290270) in the tryptophan hydroxylase-2 gene and primary insomnia and symptoms of depression in Han Chinese. 29952309 2018
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms 		0.060 GeneticVariation phenotype BEFREE Association of regulatory TPH2 polymorphisms with higher reduction in depressive symptoms in children and adolescents treated with fluoxetine. 28456685 2017
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms 		0.060 GeneticVariation phenotype BEFREE Genetic variation in the tryptophan hydroxylase 2 gene moderates depressive symptom trajectories and remission over 8 weeks of escitalopram treatment. 26745768 2016
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms 		0.060 GeneticVariation phenotype BEFREE The aim of this study was to investigate whether genetic polymorphisms in the TPH2 gene, the gene product of which is the rate-limiting enzyme in the biosynthesis of serotonin in the central nervous system, are associated with depressive symptoms in pregnancy and the postpartum period. 22721547 2012
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms 		0.060 GeneticVariation phenotype BEFREE Single marker analyses showed a significant GxE interaction with several TPH2 variants, including rs4570625, on depressive symptoms. 22868061 2012
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms 		0.060 Biomarker phenotype BEFREE Association of TPH1, TPH2, and 5HTTLPR with PTSD and depressive symptoms. 22483952 2012