Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Local gyrification index in patients with major depressive disorder and its association with tryptophan hydroxylase-2 (TPH2) polymorphism. 27807918 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE These results suggested that genotypic variation in TPH2 may moderate the therapeutic response to esciatlopram among Chinese patients with MDD. 26745768 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE Interaction of tryptophan hydroxylase 2 gene and life events in susceptibility to major depression in a Chinese Han population. 26386440 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 AlteredExpression disease BEFREE Methylation of the tryptophan hydroxylase‑2 gene is associated with mRNA expression in patients with major depression with suicide attempts. 25955598 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Accumulating evidences suggest that Tryptophan hydroxylase 2 (TPH2) gene is associated with major depressive disorder (MDD) and cognitive function. 26057341 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease PSYGENET Single locus analysis in pooled and ethnically stratified subjects revealed no association between each of the three variants of the TPH2 gene with susceptibility to MDD. 24376086 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease PSYGENET The results of our analysis indicated no significant differences in the frequencies of the single alleles and genotypes of two polymorphisms in TPH2 gene between LOD patients and normal controls. 26057341 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease PSYGENET Polymorphisms in the gene encoding the serotonin synthesis enzyme Tph2 have been identified in mental illnesses, including bipolar disorder, major depression, autism, schizophrenia, and ADHD. 24196946 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease PSYGENET Here we use chronic multicircuit neurophysiological recordings to characterize functional interactions across cortical and limbic circuits in mice engineered to express a human loss-of-function depression allele Tph2-(R441H) [Tph2 knockin (Tph2KI)]. 23467366 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (Tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major depressive disorder, the circuit level alterations that results from serotonergic hypofunction remain poorly understood. 23467366 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease PSYGENET A rare mutation in tryptophan hydroxylase 2 (Tph2), the rate limiting enzyme for 5-HT synthesis, was identified in several patients with major depression, and knock-in mice expressing the analogous mutation (R439H Tph2 KI) show 80% reduction in 5-HT synthesis and tissue levels. 23336047 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE In total, 14 single nucleotide polymorphisms (SNPs) in coding regions of 10 serotonergic genes (HTR1A, HTR1B, HTR1D, HTR2A, HTR3A, HTR3C, HTR3D, HTR3E, HTR5A and TPH2) were genotyped in 308 Chinese Han patients with major depressive disorder. 21937687 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE TPH2 gene polymorphisms and major depression--a meta-analysis. 22693556 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Influence of TPH2 variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia. 21396719 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE Tryptophan hydroxylase 2 gene is associated with major depressive disorder in a female Chinese population. 21620479 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Effect of tryptophan hydroxylase-2 rs7305115 SNP on suicide attempts risk in major depression. 20738857 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Those who did not drink alcohol before suicide were more likely to have a diagnosis of major depressive disorder in their medical record and more often had the TT genotype of the tryptophan hydroxylase 2 gene. 19734157 2010
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Population-specific functional variant of the TPH2 gene 2755C>A polymorphism contributes risk association to major depression and anxiety in Chinese peripartum women. 19588223 2010
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response. 19272410 2009
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression. 19590397 2009
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 AlteredExpression disease BEFREE The mechanisms underlying these changes are uncertain, but increased TPH2 expression and serotonin turnover could result from genetic influences, adverse early life experiences, or acute stressful life events, all of which can alter serotonergic neurotransmission and have been implicated in determining vulnerability to major depression. 19120094 2009
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE TPH2 -703G/T SNP may have important effect on susceptibility to suicidal behavior in major depression. 19162119 2009
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE Hence, the results suggest that in this particular group of stress-induced depression patients TPH-1 appears to be more relevant to MD pathogenesis than TPH-2. 17692928 2008
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression. 18180764 2008
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE Markers in TPH2 have been implicated in suicide and major depressive disorder, but the results across studies are inconsistent. 16806105 2007