Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Tryptophan hydroxylase-2 polymorphism is associated with white matter integrity in first-episode, medication-naïve major depressive disorder patients.
|
30822678 |
2019 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
BEFREE |
The Interaction of TPH2 and 5-HT2A Polymorphisms on Major Depressive Disorder Susceptibility in a Chinese Han Population: A Case-Control Study.
|
31019472 |
2019 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
TPH-2 Gene Polymorphism in Major Depressive Disorder Patients With Early-Wakening Symptom.
|
30519155 |
2018 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Local gyrification index in patients with major depressive disorder and its association with tryptophan hydroxylase-2 (TPH2) polymorphism.
|
27807918 |
2017 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
TPH2 rs4290270 was genotyped in 165 suicide attempters and 188 suicide non-attempters diagnosed with major depressive disorder, bipolar disorder and schizophrenia.
|
28084537 |
2017 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between TPH2 gene polymorphisms with major depressive disorder in multiethnic Malaysian population.
|
24376086 |
2015 |
Unipolar Depression
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Methylation of the tryptophan hydroxylase‑2 gene is associated with mRNA expression in patients with major depression with suicide attempts.
|
25955598 |
2015 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
PSYGENET |
Lack of association between TPH2 gene polymorphisms with major depressive disorder in multiethnic Malaysian population.
|
24376086 |
2015 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
PSYGENET |
Tryptophan hydroxylase 2 gene is associated with cognition in late-onset depression in a Chinese Han population.
|
26057341 |
2015 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Three TPH2 polymorphisms, -703G/T (rs4570625), -473T/A (rs11178997), and 1463G/A (rs120074175), were selected based on previous findings of associations with MD.
|
26386440 |
2015 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
PSYGENET |
Polymorphisms in the gene encoding the serotonin synthesis enzyme Tph2 have been identified in mental illnesses, including bipolar disorder, major depression, autism, schizophrenia, and ADHD.
|
24196946 |
2014 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (Tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major depressive disorder, the circuit level alterations that results from serotonergic hypofunction remain poorly understood.
|
23467366 |
2013 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
MGD |
Although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (Tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major depressive disorder, the circuit level alterations that results from serotonergic hypofunction remain poorly understood.
|
23467366 |
2013 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
PSYGENET |
Although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (Tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major depressive disorder, the circuit level alterations that results from serotonergic hypofunction remain poorly understood.
|
23467366 |
2013 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
PSYGENET |
A rare mutation in tryptophan hydroxylase 2 (Tph2), the rate limiting enzyme for 5-HT synthesis, was identified in several patients with major depression, and knock-in mice expressing the analogous mutation (R439H Tph2 KI) show 80% reduction in 5-HT synthesis and tissue levels.
|
23336047 |
2013 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In total, 14 single nucleotide polymorphisms (SNPs) in coding regions of 10 serotonergic genes (HTR1A, HTR1B, HTR1D, HTR2A, HTR3A, HTR3C, HTR3D, HTR3E, HTR5A and TPH2) were genotyped in 308 Chinese Han patients with major depressive disorder.
|
21937687 |
2012 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
TPH2 gene polymorphisms and major depression--a meta-analysis.
|
22693556 |
2012 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that TPH2 variants neither have a major role in MD, BD and schizophrenia nor in response to treatments.
|
21396719 |
2011 |
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
BEFREE |
Tryptophan hydroxylase 2 gene is associated with major depressive disorder in a female Chinese population.
|
21620479 |
2011 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Effect of tryptophan hydroxylase-2 rs7305115 SNP on suicide attempts risk in major depression.
|
20738857 |
2010 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Those who did not drink alcohol before suicide were more likely to have a diagnosis of major depressive disorder in their medical record and more often had the TT genotype of the tryptophan hydroxylase 2 gene.
|
19734157 |
2010 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, an increased frequency of G allele of TPH2 SNP may be associated with elevated suicidal behavior itself rather than with the diagnosis of major depression and may increase risk of suicidality, independent of diagnosis.
|
19162119 |
2009 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression.
|
19590397 |
2009 |
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Although the sample size is small, results from this study suggest that the TPH2 C2755A polymorphism may represent a population-specific risk factor for peripartum major depression and anxiety disorder, perhaps by interacting with hormones.
|
19588223 |
2009 |
Unipolar Depression
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
The mechanisms underlying these changes are uncertain, but increased TPH2 expression and serotonin turnover could result from genetic influences, adverse early life experiences, or acute stressful life events, all of which can alter serotonergic neurotransmission and have been implicated in determining vulnerability to major depression.
|
19120094 |
2008 |