CCR4, C-C motif chemokine receptor 4, 1233

N. diseases: 168; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma
0.280 Biomarker disease BEFREE Publisher Correction: A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma. 29700309 2018
CUI: C0004096
Disease: Asthma
Asthma
0.280 Biomarker disease BEFREE The acquisition of CD15S, CD39, CD101, and CCR4 contributed to the increased heterogeneity of Regulatory T cells during asthma. 30087444 2018
CUI: C0004096
Disease: Asthma
Asthma
0.280 Biomarker disease BEFREE Because CCL22-mediated activation of CCR4 plays a role in Th2 cell regulation in asthmatic inflammation, we hypothesized that CCR4-mediated migration of CD4<sup>+</sup> Th2 cells to the lung in asthma may use β-arr-dependent signaling. 29361236 2018
CUI: C0004096
Disease: Asthma
Asthma
0.280 Biomarker disease BEFREE A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma. 29118379 2017
CUI: C0004096
Disease: Asthma
Asthma
0.280 Biomarker disease BEFREE CCL17-induced, CCR4-dependent release of CGRP by human airway epithelial cells represents a novel inflammatory pathway and a possible target in patients with asthma and allergic disease. 23731651 2013
CUI: C0004096
Disease: Asthma
Asthma
0.280 AlteredExpression disease BEFREE Activation of CCR4 by CKLF1 plays an important role in diseases such as asthma and multiple sclerosis. 20099827 2010
CUI: C0004096
Disease: Asthma
Asthma
0.280 Biomarker disease RGD Elevated expression of TARC (CCL17) and MDC (CCL22) in models of cigarette smoke-induced pulmonary inflammation. 15993846 2005
CUI: C0004096
Disease: Asthma
Asthma
0.280 Biomarker disease BEFREE Although the total numbers of cells expressing CCR4, CCR8, and CXCR3 did not significantly differ in the asthmatics and controls, there was evidence of selective infiltration of CD4(+)/CCR4(+) T cells in the asthmatic biopsies which correlated with TARC and MDC expression and airway obstruction. 15944327 2005
CUI: C0004096
Disease: Asthma
Asthma
0.280 AlteredExpression disease BEFREE CXCR4 and CCR4 are the major chemokine receptor genes expressed in the giant papillae of AKC with atopic dermatitis and/or asthma. 15788997 2005