CCR4, C-C motif chemokine receptor 4, 1233

N. diseases: 168; N. variants: 1
Disease: Leukemia, T-Cell ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.060 AlteredExpression disease BEFREE Although the anti-CCR4 antibody mogamulizumab (moga) shows striking antitumor activity against adult T cell leukemia (ATL), it can also cause fatal immunological pathology such as severe skin rash and graft-versus-host disease, which might be attributed to depletion of CCR4<sup>+</sup> regulatory T cells. 29399406 2018
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.060 Biomarker disease BEFREE Galectin-9 as a Predictive Marker for the Onset of Immune-Related Adverse Effects Associated with Anti-CCR4 MoAb Therapy in Patients with Adult T Cell Leukemia. 28321034 2017
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.060 Biomarker disease BEFREE Mogamulizumab (Mog), a humanized anti-CC chemokine receptor 4 (CCR4) mAb that mediates antibody-dependent cellular cytotoxicity (ADCC) using FcγR IIIa (CD16)-expressing effector cells, has recently been approved for treatment of CCR4-positive adult T-cell leukemia (ATL) in Japan. 27091408 2016
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.060 AlteredExpression disease BEFREE Since HTLV-1 Tax does not induce CCR4 expression, transcription factor(s) constitutively active in ATL may be responsible for its strong expression. 18071306 2008
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.060 Biomarker disease BEFREE Previously, we and others have shown that the majority of ATL cases are strongly positive for CCR4, which may explain the frequent skin invasion of ATL. 17205512 2007
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.060 AlteredExpression disease BEFREE Collectively, most ATL cases have apparently derived from CD4(+) T cells expressing CCR4. 11861261 2002
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.060 AlteredExpression disease LHGDN Collectively, most ATL cases have apparently derived from CD4(+) T cells expressing CCR4. 11861261 2002