CCR4, C-C motif chemokine receptor 4, 1233

N. diseases: 168; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1519680
Disease: Tumor Immunity
Tumor Immunity
0.030 AlteredExpression phenotype BEFREE Exploiting this approach to develop a therapeutic modality for T cell malignancies for which the available regimens are neither curative, nor confer long term survival we generated a lentivirus-based CAR gene transfer system to target the chemokine receptor CCR4 that is over-expressed in a spectrum of T cell malignancies as well as in CD4<sup>+</sup> CD25<sup>+</sup> Foxp3<sup>+</sup> T regulatory cells that accumulate in the tumor microenvironment constituting a barrier against anti-tumor immunity. 28543380 2017
CUI: C1519680
Disease: Tumor Immunity
Tumor Immunity
0.030 Biomarker phenotype BEFREE A CCR4 antagonist combined with vaccines induces antigen-specific CD8+ T cells and tumor immunity against self antigens. 21908423 2011
CUI: C1519680
Disease: Tumor Immunity
Tumor Immunity
0.030 Biomarker phenotype BEFREE Our data suggest not only that the CCR4 molecule could be a suitable target for the novel antibody-based therapy for patients with ATLL but also that KM2760 may induce effective tumor immunity by reducing the number of regulatory T cells. 15569983 2004