COL1A1, collagen type I alpha 1 chain, 1277

N. diseases: 487; N. variants: 337
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 GeneticVariation disease BEFREE α7KO mice fed an AD showed significant upregulation of the Col1a1 gene encoding alpha-1 type I collagen, which is involved in liver fibrosis, and the Ccl2 gene encoding C-C motif chemokine ligand 2, a pro-inflammatory chemokine; α7KO mice fed an MCD had significant upregulation of the Col1a1 gene and the Tnf gene, an inflammatory cytokine. 30369082 2019
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 AlteredExpression disease BEFREE Here, the relationship between SM α-actin and type 1 collagen expression (COL1A1), a major extracellular matrix protein important in liver fibrosis, is investigated with the results demonstrating that knockout of SM α-actin leads to reduced liver fibrosis and COL1 expression. 31476284 2019
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 AlteredExpression disease BEFREE COL1A1 can precisely control sTβRII expression to inhibit excessive bioactive TGF-β level and thus inhibit hepatic fibrosis but without inducing autoimmune responses. 29934723 2018
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 AlteredExpression disease BEFREE It also effectively inhibited the expression of two representative collagen proteins (COL1A1 and α-SMA) on both the mRNA and protein levels and showed a high safety profile in vivo, indicating its great promise as an anti-liver fibrosis agent. 29976890 2018
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 AlteredExpression disease BEFREE The mRNA expression levels of markers of liver fibrosis [alpha-smooth muscle actin (α-SMA) and collagen 1A1 (Col1A1)] were analyzed by quantitative reverse transcription-polymerase chain reaction (RT-PCR). 30522100 2018
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 Biomarker disease BEFREE Finally, we experimentally confirmed a functional regulatory module containing 5 miRNAs (miR-130b-3p, miR-148a-3p, miR-345-5p, miR-378a-3p, and miR-422a) and 6 genes (COL6A1, COL6A2, COL6A3, PIK3R3, COL1A1, CCND2) associated with liver fibrosis. 28919164 2017
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 AlteredExpression disease BEFREE Compared with CCl<sub>4</sub> injection alone, CCl<sub>4</sub> plus LPS injection exaggerated liver fibrosis in mice, as demonstrated by increased Col1a1 (collagen, type I, α 1), Acta2, Tgfb and Timp1 mRNA expression, ACTA2/α-SMA and COL1A1 protein expression, and Sirius Red staining area, which could be attenuated by injection of an autophagy inhibitor. 29160747 2017
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 Biomarker disease BEFREE There was additionally a negative correlation between serum lincRNA-p21 level and the markers of liver fibrosis including α-SMA and Col1A1. 28107589 2017
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 AlteredExpression disease BEFREE In vitro analysis using LX2 HSC cells indicated that AT‑II can augment TGF‑β1 and collagen type I α1 mRNA expression via periostin expression, suggesting that the interaction between AT‑II and periostin may serve a role in liver fibrosis development. 28849131 2017
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 AlteredExpression disease BEFREE Infusion of Ang-(1-7) alleviated BDL-induced liver fibrosis and inhibited the expression of Col1A1 and the activation of NLRP3 inflammasome in hepatocytes. 27445100 2016
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 Biomarker disease CTD_human Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis. 26396155 2016
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 Biomarker disease CTD_human Ascorbic acid suppresses endotoxemia and NF-κB signaling cascade in alcoholic liver fibrosis in guinea pigs: a mechanistic approach. 24239723 2014
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 Biomarker disease CTD_human Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs. 24321339 2014
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.400 Biomarker disease CTD_human Cannabinoid receptor type I modulates alcohol-induced liver fibrosis. 21863215 2011