|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the catechol-O-methyl transferase (COMT) gene have been associated with alcoholism, suggesting that alterations in the metabolism of catecholamines may be a critical component of the neuropathology of alcoholism.
|
29310047 |
2018 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A functional COMT polymorphism, Val158Met (rs4680 G > A), affects the onset of AD and is associated with alcohol dependence through dopamine receptor sensitivity in the prefrontal cortex.
|
25491588 |
2015 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study provides data from a sample of ethnically homogeneous unrelated Caucasian subjects for future meta-analyses and suggests that the increased platelet MAO-B activity might be used as independent peripheral indicator of alcohol dependence, while COMT Val108/158Met polymorphism is associated with increased suicidality and early onset of alcohol dependence.
|
25035107 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study tested the hypothesis that genetic variation in COMT Val158Met and DRD2/ANKK1 Taq1A interacts with childhood adverse experiences to predict alcohol dependence.
|
22509987 |
2013 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
COMT Val158Met and DRD2 Taq1A may confer their risk of alcohol dependence through reduced dopamine receptor sensitivity in the prefrontal cortex and hindbrain, respectively.
|
22474103 |
2012 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association study of a functional catechol-O-methyltransferase (COMT) Val108/158Met polymorphism and suicide attempts in patients with alcohol dependence.
|
20860878 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It is possible that the rs165774 SNP, in combination with rs4680, results in a common molecular variant of COMT that contributes to schizophrenia and alcohol dependence susceptibility.
|
22208661 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conducted an association study on the products encoded by 10 DA-related genes (DRD1-D5, SLC18A2, SLC6A3, DDC, TH, COMT) using a large, ethnically homogeneous sample with severe AD (n = 545) and screened controls (n = 509).
|
21083670 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the association of COMT genotype at this locus with blood pressure (BP) in 839 alcohol-dependent individuals before and during participation in an alcoholism treatment trial.
|
19023276 |
2009 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Despite the substantial size of this study, we did not find evidence to support an association between alcohol dependence or habitual smoking and variation in COMT.
|
17850222 |
2007 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In addition, a common Met158 variant in the catechol-O-methyltransferase (COMT) gene can confer both risk and resilience to alcoholism in different drinking environments.
|
17347351 |
2006 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Family-based and case-control study of DRD2, DAT, 5HTT, COMT genes polymorphisms in alcohol dependence.
|
17079080 |
2006 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aims of our study were firstly to investigate patterns of alcohol and tobacco consumption and comorbidity between alcoholism and smoking in Plains American Indians and secondly to determine the influence, including sexual dimorphic effects, of COMT Val158Met and COMT haplotypes, on these behaviors.
|
16499480 |
2006 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This suggests that the catechol-O-methyltransferase gene polymorphism is not associated with the development of alcohol dependence, but may affect the susceptibility to a clinical heterogeneity of alcohol dependence, at least in the Korean population.
|
15900232 |
2005 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse.
|
15584875 |
2004 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
LHGDN |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse.
|
15584875 |
2004 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The genes of potential interest fell into several categories, including second-messenger systems (e.g., G proteins, adenylyl cyclase, and protein kinases); neurotransmitters or drug-related receptors (e.g., gamma-aminobutyric acid-A, glutamate, serotonin, and cannabinoid and opioid receptors); genes that affect alcohol metabolism; and genes that might relate to an overlap in the risk for alcoholism and some psychiatric conditions (e.g., catechol-O-methyltransferase regarding schizophrenia and bipolar disorder).
|
15597076 |
2004 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
BEFREE |
A functional genetic polymorphism of the enzyme catechol-O-methyltransferase (COMT) that participates in converting dopamine into its final metabolite HVA was investigated for an association with alcoholism or DT during alcohol withdrawal.
|
12741370 |
2003 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
BEFREE |
The presentations were (1) Two functional polymorphisms and their intermediate phenotypes in complex behaviors: COMT/executive cognition and anxiety and HTT/anxiety, by David Goldman; (2) Role of the EEG in determining genetic risk for alcoholism and anxiety disorders, by Mary-Anne Enoch; (3) The response to alcohol as an intermediate phenotype for alcoholism, by Marc A. Schuckit; and (4) Pharmacogenomic approaches to alcoholism treatment: toward a hypothesis, by Bankole A. Johnson.
|
12605066 |
2003 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results provide further evidence for an involvement of the COMT low-activity allele in the development of alcoholism and demonstrate the need for further studies in large samples of alcoholic patients.
|
11244495 |
2001 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The COMT genotype was determined in 62 impulsive violent recidivist offenders with early-onset (type 2) alcoholism, 123 late-onset nonviolent (type 1) alcoholics, and 267 race and gender-matched controls.
|
10898913 |
2000 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A common functional polymorphism that results in a three- to four-fold difference in catechol-O-methyltransferase (COMT) enzyme activity has been related to psychiatric disorders such as ultra-ultra rapid cycling bipolar disorder, drug abuse and alcoholism (Lachman et al., 1996a; Karayiorgou et al., 1997; Vandenbergh et al., 1997; Papolos et al., 1998; Tiihonen et al., 1999).
|
11204347 |
2000 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have shown that type I alcoholism is more common among subjects with low activity COMT genotype (LL), compared with high activity (HH) or heterozygotic (LH) genotypes.
|
10698363 |
2000 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, the COMT gene is not likely to play a significant role in alcoholism.
|
10551543 |
1999 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
CTD_human |
It has been suggested that a common functional genetic polymorphism in the COMT gene, which results in 3 to 4-fold difference in COMT enzyme activity, may contribute to the etiology of mental disorders such as bipolar disorder and alcoholism.
|
10395222 |
1999 |