|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Specifically, the Val<sup>158</sup>Met polymorphism greatly alters COMT function and cognitive performance in both psychiatric disorders and healthy controls.
|
30146088 |
2019 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
COMT gene polymorphism is associated with mental disorders and sensitivity to pain.
|
30881091 |
2019 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
COMT is a known neuropsychiatric candidate gene, which contains a genotype variant (Val<sup>108/158</sup>Met) that affects protein function and has been found associated with several psychiatric disorders.
|
31587837 |
2019 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The present study appears to be the first comprehensive meta-analysis of COMT genetic association studies to cover all psychiatric disorders for which there were available data, published in any language, and with an emphasis on investigating disorder subtypes (defined clinically or by demographic or other variables).
|
28608575 |
2018 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The Catechol-O-methyltransferase (COMT) gene has been an important candidate risk factor for several psychiatric disorders.
|
28235603 |
2017 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The COMT Val<sup>158</sup>Met genotype and PTSD association persists after controlling for race (multivariable OR of 0.29, 95% CI [0.10-0.83]) and pre-existing psychiatric disorders/substance abuse (multivariable OR of 0.32, 95% CI [0.11-0.97]).
|
27769642 |
2017 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The relationship between proline and COMT also appears to modify negative symptoms across psychiatric illness.
|
27622935 |
2016 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Due to its role in neurotransmitter flux, multiple COMT variants have been associated with the development of psychiatric disorders.
|
27228319 |
2016 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Further research with larger samples is needed to explore the interactions of the COMT gene rs4680 polymorphism and sex and psychiatric disorders on suicide attempts.
|
27203226 |
2016 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Among the genes in the deleted region, catechol-O-methyltransferase (COMT) has a particular relevance for psychiatric disorders: lower COMT enzymatic activity decreases the clearance of dopamine (DA), yielding higher levels of catecholamines in the central nervous system.
|
27548835 |
2016 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Since recent studies in patients affected by neurodegenerative and psychiatric disorders suggested a role of saitohin (STH) gene as a concurring factor in hypofrontality, we hypothesize that STH and COMT polymorphisms could have an additive effect on cognition in schizophrenia.
|
25283873 |
2015 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Additionally, these findings contribute to the growing literature on sex-specific effects of COMT on the predisposition to psychiatric disorders and personality traits.
|
25722988 |
2015 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Increasing evidence suggests that the catechol-O-methyltransferase (COMT) gene might be associated with cognition in patients with mental disorders and healthy people.
|
24373005 |
2014 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A functional polymorphism COMT Val158Met has been associated with psychiatric disorders including suicidal behavior.
|
24389396 |
2014 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and drug-related psychiatric disorders.
|
24708432 |
2014 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis.
|
23799032 |
2013 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Catechol O-methyltransferase (COMT) has been associated with aggression, attention deficit/hyperactivity disorder (ADHD), and other psychiatric disorders.
|
22972758 |
2013 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Many association studies have reported associations between the catechol-O-methyltransferase (COMT) gene and psychiatric disorders including major depression (MDD).
|
21940152 |
2012 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Many clinical and genomic association studies suggested that the catechol-O-methyltransferase (COMT) gene region was an important genetic locus for psychiatric disorders, because of the proposed relationship between its function in catecholaminergic neurotransmission and individual response to antidepressants, and vulnerability to psychiatric disorders.
|
22483292 |
2012 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
One of its most widely studied variations comprises a common single nucleotide polymorphism (SNP), a valine-to-methionine substitution at codon 158 (COMT Val158Met), which has been associated with various cognitive phenotypes, psychiatric disorders and changes in brain activation and structure.
|
22138198 |
2012 |
|
Mental disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
These preliminary data suggest that low COMT activity may affect dopamine levels in striatum in humans and this may have implications for understanding the contribution of COMT activity to psychiatric disorders.
|
21465565 |
2011 |
|
Mental disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
To examine, in a sample of young psychiatric patients, (n = 157, mean age 17.01 years (SD = 3.6)) whether i) age at first cannabis use and age at emergence of psychiatric disorders are related and ii) such a relationship is modulated by the Val158Met polymorphism in the COMT gene.
|
21231925 |
2011 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
This study examined the association of COMT with salivary cortisol across a 1-year period in healthy and at-risk adolescents with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision Axis II diagnoses.
|
20421850 |
2010 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Catechol-O-methyltransferase (COMT) is a candidate gene for the pathogenesis of some psychiatric disorders.
|
20004480 |
2010 |
|
Mental disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The gene encoding Catechol O-methyltransferase (COMT), a dopamine catabolic enzyme, is an important candidate gene in several psychiatric disorders.
|
20605701 |
2010 |