COMT, catechol-O-methyltransferase, 1312

N. diseases: 622; N. variants: 47
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders
0.400 GeneticVariation group BEFREE This study investigates whether genotypes associated with reduced prefrontal dopaminergic tone and/or reduced dopamine D2-receptor availability (Catechol-O-methyltransferase [COMT] Val<sup>158</sup> Met genotype and DRD2 C<sup>957</sup> T genotype) affect the development of cognitive deficits in PD. 28869277 2018
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders
0.400 GeneticVariation group BEFREE A single-nucleotide polymorphism in catechol-o-methyltransferase (COMT), an enzyme which degrades catecholamine neurotransmitters, may influence cognitive deficits following moderate and/or severe head trauma. 26576546 2016
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders
0.400 GeneticVariation group BEFREE While the high activity alleles of variants within COMT have been associated with cognitive deficits, and the low activity alleles with higher risk of anxiety disorders, no associations of COMT with PEs have been found. 24862404 2014
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders
0.400 Biomarker group BEFREE In conclusion, in view of therapeutic efficacy, we can envisage indications for future investigations into the role of COMT for sleep regulation, cognitive performance and sleep-related cognitive deficits. 22483299 2012
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders
0.400 GeneticVariation group BEFREE Psychosocial functioning and cognitive deficits are not associated with membrane-bound catechol-O-methyltransferase deoxyribonucleic acid methylation in siblings of patients with schizophrenia. 23124177 2012
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders
0.400 GeneticVariation group BEFREE Catechol-O-methyltransferase genotype modulates cancer treatment-related cognitive deficits in breast cancer survivors. 21425136 2011
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders
0.400 AlteredExpression group BEFREE The aim of the present study was to better characterize the cognitive phenotype in a large cohort children with 22q11DS compared with sibling controls and to investigate if the cognitive deficits in 22q11DS were modulated by COMT expression. 20307169 2010
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders
0.400 AlteredExpression group BEFREE Genetic variation in D2 type DA receptors and the catechol-O-methyltransferase enzyme appears to moderate cognitive deficits induced by smoking abstinence. 20456288 2010
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders
0.400 Biomarker group BEFREE Treatment of cognitive deficits associated with schizophrenia: potential role of catechol-O-methyltransferase inhibitors. 17579498 2007
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders
0.400 Biomarker group CTD_human COMT val108/158met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia. 17123785 2007
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders
0.400 Biomarker group BEFREE We conclude by outlining preliminary data indicating that COMT is a promising therapeutic target for ameliorating the cognitive deficits associated with schizophrenia. 16476412 2006