|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we sought to examine the independent and joint contributions of low COMT and stress to chronic functional pain and depression at the behavioral and molecular level.
|
31815911 |
2019 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A meta-analysis study suggested the link between COMT SNPs and MDD risk; in addition, MB membrane-bound (MB-COMT) specific genetic variation was reported that influences predisposition to depression amongst females.
|
30597299 |
2019 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Catechol-O-Methyltransferase (COMT) rs4680 Val158Met Polymorphism is Associated With Widespread Pressure Pain Sensitivity and Depression in Women With Chronic, but not Episodic, Tension-Type Headache.
|
30614828 |
2019 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Some nominal associations were found for the depressive phenotype. rs10997871 and rs10997875 within SIRT1 were nominally associated with depression in the total sample and in the Greek subsample. rs174696 within COMT was associated with depression comorbidity in the Italian subsample.
|
31096213 |
2019 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In contrast, COMT Val allele homozygosity was associated with depression (OR = 4.34).
|
29627597 |
2018 |
|
Mental Depression
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Differential effect of COMT gene methylation on the prefrontal connectivity in subjects with depression versus healthy subjects.
|
29723539 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Both additive interaction (attributable proportion (AP) = 0.56; 95% CI: 0.24-0.90 and synergy index (SI) = 4.39; 1.0-18.7) and multiplicative interaction (log likelihood test p = 0.1) was present between depression and COMT Val<sup>158</sup>Met in predicting risk of later CVD.
|
30045690 |
2018 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Simple regression analysis was performed between pain intensity numerical rating scale (NRS) (day 8) as the dependent variable, expectation of pain decrease NRS (day 1), tumor types, and the following covariates as independent variables: patients' characteristics such as age, gender, PS (day 1), genotype of catechol-O-methyltransferase, total scores of Hospital Anxiety and Depression Scale (day 1), and pain intensity NRS (day 1).
|
28265809 |
2017 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We stratified PD by status of depression and the association between COMT rs6267 "GT" genotype and pain severity remained significant (P < 0.01).
|
28740224 |
2017 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our study demonstrated nonlinear modulation of the interaction between COMT and depression on brain function.
|
28728097 |
2017 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this observational prospective study, we recorded patient characteristics, pre-operative pain intensity, anxiety and depression levels, sensitivity and pain thresholds in response to an electrical stimulus, and mu-opioid receptor (OPRM1) and catechol-O-methyltransferase (COMT) single-nucleotide polymorphisms.
|
26517014 |
2016 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our research suggests that women with polymorphisms in COMT were less susceptible to depressive symptoms but these polymorphisms do not appear to influence susceptibility to depression in those exposed to life stressors.
|
27347613 |
2016 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
FEP patients with depression showed increased COMT expression and decreased NDEL1 expression.
|
26491028 |
2016 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
COMT and ANKK1 Genetics Interact With Depression to Influence Behavior Following Severe TBI: An Initial Assessment.
|
27154305 |
2016 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our study substantiates the involvement of the MAOA and MTHFR polymorphisms in climacteric depression and offers evidence that the COMT and ESR1 genes may also play a role in the susceptibility to depressive mood in postmenopausal women.
|
26620113 |
2016 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
COMT and the DAT regulate dopamine availability in the prefrontal cortex and the striatum, respectively, two key regions recruited during learning, whereas dopamine D1 and D2 receptors are thought to be involved in long-term potentiation and depression, respectively.
|
26419600 |
2015 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
None of the COMT alleles were associated with depression.
|
25451452 |
2015 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
An interaction with catechol-O-methyltransferase (COMT) has also been proved affecting depression.
|
26021967 |
2015 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
All patients were evaluated by using the Geriatric Depression Scale, disease progression was recorded, and GNβ3 and COMT were genotyped by PCR.
|
25037115 |
2014 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Brooding rumination and heart rate variability in women at high and low risk for depression: group differences and moderation by COMT genotype.
|
24661160 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Genotypes for the COMT Val158Met and DRD4 VNTR-48 polymorphisms and TCI Harm Avoidance and MMPI Depression scales' scores were obtained as well.
|
25011686 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
FMR1 gene polymorphisms, dopaminergic (DAT, DRD, COMT), serotonin (5-HTTLPR, HTR1A, HTR2A), interleukins, MCR1, HCN (potassium channel), neurorregulinas, GABAergic (GABA, GAD, DBI) DBI, GABA (Gabra) receptors and GAD genes (GAD1, GAD2) appear to contribute to generate condition of depression or anxiety like.
|
25106036 |
2014 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, we aimed to examine whether the COMT-MTHFR genotype interacted with cognitive function in late-onset depression (LOD) patients and COMT Val/Val homozygous individuals who also carried the MTHFR T allele and had poor neuropsychological test performance.
|
24373005 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings endorse the association of BDNF and COMT with stress and depression and provide a possible intermediate, i.e. biased processing of positive information.
|
24589356 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The present study investigated the effects of familial risk for depression and the 5-HTTLPR and COMT Val158Met polymorphisms, which have been associated with risk for depression, on biases in endorsement of and memory for positive and negative adjectives.
|
24679392 |
2014 |