|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, we aimed to establish the acute effects of administration of cannabis and cocaine on valence-dependent reversal learning as a function of DRD2 Taq1A (rs1800497) and COMT Val108/158Met (rs4680) genotype.
|
26572896 |
2016 |
|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Working memory following cannabis acutely was worse in females, with some suggestion of an impact of COMT polymorphism on working memory when drug-free.
|
26882038 |
2016 |
|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Epidemiological and retrospective studies suggest a cannabis x catechol-O-methyltransferase (COMT) Val(158)Met interaction effect on development of psychosis.
|
27052366 |
2016 |
|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A functional polymorphism in the catechol-O-methyltransferase (COMT) gene (Val(158)Met) appears to influence the immediate cognitive and psychotic effects of cannabis, or ∆(9)-tetrahydrocannabinol (THC), its primary psychoactive ingredient.
|
26464454 |
2015 |
|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, according to our socio-economical survey, COMT genotype has no association with cannabis but it is strongly associated with tobacco.
|
25801838 |
2015 |
|
Marijuana Abuse
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Adolescents with the Met/Met genotype and high rates of MB-COMT promoter methylation were less likely to be high-frequent cannabis users than adolescents with the Val/Val or Val/Met genotype.
|
24902721 |
2014 |
|
Marijuana Abuse
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The results showed that the COMT polymorphism influenced the volume of the bilateral ventral caudate nucleus in both groups, but in an opposite direction: more copies of val allele led to lesser volume in chronic cannabis users and more volume in controls.
|
23311613 |
2014 |
|
Marijuana Abuse
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Adolescents with the Met/Met genotype and high rates of MB-COMT promoter methylation were less likely to be high-frequent cannabis users than adolescents with the Val/Val or Val/Met genotype.
|
24902721 |
2014 |
|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Psychosis-inducing effects of cannabis are related to both childhood abuse and COMT genotypes.
|
23445265 |
2014 |
|
Marijuana Abuse
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Cannabis users carrying the COMT val/val genotype exhibited lower accuracy of sustained attention, associated with a more strict response bias, than val/val non-users.
|
23449176 |
2013 |
|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
COMT val158met and 5-HTTLPR genetic polymorphisms moderate executive control in cannabis users.
|
23449176 |
2013 |
|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A putative interaction between cannabis and variation at rs4680 within the catechol-methyl-transferase (COMT) gene on psychosis has been reported, but not adequately replicated.
|
21947654 |
2011 |
|
Marijuana Abuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we present a case-only study of the putative COMT-cannabis interaction in schizophrenia.
|
21310591 |
2011 |
|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The COMT Val158Met genotype seems to modulate the association between cannabis and age at onset of psychotic disorders.
|
21231925 |
2011 |
|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There were no effects of COMT genotype or genotype by early cannabis onset interactions.
|
19944543 |
2010 |
|
Marijuana Abuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
The cannabis-COMT interaction showed a significant effect on both DUP and age of onset.
|
20493536 |
2010 |
|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cannabis has been reported as a likely risk factor for the development of psychosis, and a gene × environment interaction with the catechol-O-methyltransferase (COMT) gene has been proposed.
|
19633959 |
2009 |
|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The findings confirm that in people with psychometric evidence of psychosis liability, COMT Val(158)Met genotype moderates the association between cannabis and psychotic phenomena in the flow of daily life.
|
18808401 |
2009 |
|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We also examined a putative interaction between cannabis and Val(158)Met within the catechol-O-methyltransferase gene (COMT).
|
17978319 |
2007 |
|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Observational studies have suggested that psychometric psychosis liability and a functional polymorphism in the catechol-O-methyltransferase (COMT Val(158)Met) gene moderate the psychosis-inducing effect of cannabis.
|
16936704 |
2006 |
|
Marijuana Abuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Carriers of the COMT valine158 allele were most likely to exhibit psychotic symptoms and to develop schizophreniform disorder if they used cannabis.
|
15866551 |
2005 |