COMT, catechol-O-methyltransferase, 1312

N. diseases: 622; N. variants: 47
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030193
Disease: Pain
Pain
0.600 GeneticVariation phenotype BEFREE The primary aim of this study was to investigate the effects of the catechol-O-methyltransferase Val158Met polymorphism on heat pain perception in a cohort of adults receiving daily opioid therapy for chronic pain. 31041874 2020
CUI: C0030193
Disease: Pain
Pain
0.600 Biomarker phenotype BEFREE Catechol-O-methyltransferase (COMT) enzyme has a major role in the adjustment of catechol-dependent functions, for example, cognition, cardiac function, and pain processing. 31586564 2020
CUI: C0030193
Disease: Pain
Pain
0.600 GeneticVariation phenotype BEFREE To analyze the association between the rs4680 catechol-O-methyltransferase Val158Met polymorphism and to determine the association of this polymorphism with clinical, psychological, and pain sensitivity variables in women with episodic or chronic migraine. 30481348 2019
CUI: C0030193
Disease: Pain
Pain
0.600 Biomarker phenotype BEFREE COMT and OPRM1 may be associated with higher pain perception after surgical procedures. 31080143 2019
CUI: C0030193
Disease: Pain
Pain
0.600 GeneticVariation phenotype BEFREE The AA genotype of rs4680 or A_T_C_A/ A_T_C_A (rs6269_rs4633_ rs4818_rs4680) diplotype of COMT, combined with the AG genotype of OPRM1 A118G, showed significantly increased pressure pain threshold from butorphanol. 31806881 2019
CUI: C0030193
Disease: Pain
Pain
0.600 GeneticVariation phenotype BEFREE The association between COMT Val158Met polymorphism (rs4680) and the inter-individual differences in the response to opioid analgesic therapy was investigated in a cohort of 87 Italian paediatric patients receiving opioids for cancer pain (STOP Pain study). 30704436 2019
CUI: C0030193
Disease: Pain
Pain
0.600 GeneticVariation phenotype BEFREE Few associations replicated: morphine dose (mcg/kg) in African American children and ABCB1 rs1045642 (A allele, β = -9.30, 95% CI: -17.25 to -1.35, p = 0.02) and OPRM1 rs1799971 (G allele, β = 23.19, 95% CI: 3.27-43.11, p = 0.02); KCNJ6 rs2211843 and high pain in African American subjects (T allele, OR 2.08, 95% CI: 1.17-3.71, p = 0.01) and in congruent European Caucasian pain phenotypes; and COMT rs740603 for high pain in European Caucasian subjects (A allele, OR: 0.69, 95% CI: 0.48-0.99, p = 0.046). 30760877 2019
CUI: C0030193
Disease: Pain
Pain
0.600 Biomarker phenotype BEFREE The joint effects of low COMT and stress on functional pain and depressive-like behavior were significantly greater in females versus males. 31815911 2019
CUI: C0030193
Disease: Pain
Pain
0.600 GeneticVariation phenotype BEFREE Catechol-O-Methyltransferase (COMT) rs4680 Val158Met Polymorphism is Associated With Widespread Pressure Pain Sensitivity and Depression in Women With Chronic, but not Episodic, Tension-Type Headache. 30614828 2019
CUI: C0030193
Disease: Pain
Pain
0.600 GeneticVariation phenotype BEFREE Further the study suggested that evaluation of G472A allele of Mb.COMT gene in the patients undergoing sternotomy for monitoring pain in pre and post-surgical events. 30073475 2019
CUI: C0030193
Disease: Pain
Pain
0.600 GeneticVariation phenotype BEFREE µ-Opioid Activity in Chronic TMD Pain Is Associated with COMT Polymorphism. 31490699 2019
CUI: C0030193
Disease: Pain
Pain
0.600 GeneticVariation phenotype BEFREE Patients with the COMT G472A-AA genotype (rs4680) and KCNJ6 A1032G-A allele (rs2070995) CLBP responded differently to opioid titration, with higher pain intensity requiring higher dosing. 31269327 2019
CUI: C0030193
Disease: Pain
Pain
0.600 Biomarker phenotype BEFREE To analyze in a population from Argentina the variation of three genes involved in the control of pain pathways-two genes that code for opioid receptors (OPRM1 and OPRK1) and COMT, which codes for an important enzyme in the control of neurotransmission-and to evaluate the associations of these genes with oral pain and the need for analgesics in the population under study. 30365572 2019
CUI: C0030193
Disease: Pain
Pain
0.600 GeneticVariation phenotype BEFREE COMT gene polymorphism is associated with mental disorders and sensitivity to pain. 30881091 2019
CUI: C0030193
Disease: Pain
Pain
0.600 GeneticVariation phenotype BEFREE The aim of the study was to evaluate the association of COMT gene polymorphism with pain perception in patients after total hip replacement (THR). 30822160 2019
CUI: C0030193
Disease: Pain
Pain
0.600 Biomarker phenotype BEFREE The greatest reductions in pain were found with safinamide (Standardized mean difference = -4.83, 95% CI [-5.07 to -4.59], p < 0.0001), followed by cannabinoids and opioids, multidisciplinary team care, catechol-O-methyltransferase inhibitors, and electrical and Chinese therapies. 30153669 2018
CUI: C0030193
Disease: Pain
Pain
0.600 Biomarker phenotype BEFREE Participants with OPRM1 Asn/Asn combined with COMT Met/Met and Val/Met reported significant pain relief after placebo administration, whereas those with other combinations of the OPRM1 and COMT genotypes displayed no significant placebo effect. 30130297 2018
CUI: C0030193
Disease: Pain
Pain
0.600 GeneticVariation phenotype BEFREE Multivariate linear regression identified sex and the rs165774 COMT polymorphism as the determinants of electric pain sensitivity, whereas TMD accounts for the variability in the cold response. 29550002 2018
CUI: C0030193
Disease: Pain
Pain
0.600 GeneticVariation phenotype BEFREE Nevertheless, the results suggest a possible genetic contribution of single-nucleotide polymorphisms within the ABCB1 and COMT genes in individuals with higher levels of pain sensitivity. 29016899 2018
CUI: C0030193
Disease: Pain
Pain
0.600 GeneticVariation phenotype BEFREE The aim of this study was to investigate if genetic variants of mu, kappa, and delta opioid receptor genes (OPRM1, OPRK1, and OPRD1) and the catechol-O-methyltransferase gene (COMT) influenced the pain phenotype in patients with osteoarthritis. 29055075 2018
CUI: C0030193
Disease: Pain
Pain
0.600 GeneticVariation phenotype BEFREE In comparison, two pain-related gene SNPs (OPRM1 [rs1799971] and COMT [rs4818]) interacted with psychological factors to predict four shoulder impairment phenotypes (abduction: 5-day average loss; strength loss: 5-day average, peak, and relative loss). 30425562 2018
CUI: C0030193
Disease: Pain
Pain
0.600 Biomarker phenotype BEFREE The onset of COMT-dependent functional pain is mediated by peripheral β<sub>2</sub>- and β<sub>3</sub>-adrenergic receptors (β<sub>2</sub>- and β<sub>3</sub>ARs) through the release of the pro-inflammatory cytokines tumor necrosis factor α (TNFα), interleukin-1β (IL-1β), and interleukin-6 (IL-6). 29935309 2018
CUI: C0030193
Disease: Pain
Pain
0.600 GeneticVariation phenotype BEFREE There was a main effect of the COMT genotype on fear of medical pain (P = 0.032), and Met-allele carriers reported significantly higher fear of medical pain compared with the Val-allele (P = 0.044). 28968343 2018
CUI: C0030193
Disease: Pain
Pain
0.600 GeneticVariation phenotype BEFREE To evaluate the association between catechol-O-methyltransferase (COMT) gene polymorphisms and temporomandibular disorders (TMD), TMD pain, psychosocial impairment related to TMD, and postoperative pain. 27792797 2017
CUI: C0030193
Disease: Pain
Pain
0.600 GeneticVariation phenotype BEFREE A prospective, longitudinal study was conducted with 134 chronic non-cancer pain patients genotyped for pain perception-related catechol-O-methyltransferase haplotypes. 28182962 2017