|
Temporomandibular Joint Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The TT genotype for the COMT rs9332377 gene was highly associated with the presence of muscular TMD (P= 0.03).
|
31285095 |
2020 |
|
Temporomandibular Joint Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms in COMT rs4818 were significantly associated with myofascial pain (OR<sub>c</sub> = 2.15; CI 95%: 1.08-4.29; P = 0.02) and were borderline for painful TMD (OR<sub>c</sub> = 1.85; CI 95%: 0.97-3.51; P = 0.06) and disc displacement (OR<sub>c</sub> = 2.42; CI 95%: 1.00-5.87; P = 0.05).
|
30811655 |
2019 |
|
Temporomandibular Joint Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
µ-Opioid Activity in Chronic TMD Pain Is Associated with COMT Polymorphism.
|
31490699 |
2019 |
|
Temporomandibular Joint Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The purpose of this study was to evaluate the associations of variability in pulp sensitivity with sex, psychosocial variables, the gene that encodes for the enzyme catechol-O-methyltransferase (COMT), and chronic painful conditions (temporomandibular disorders [TMDs]).
|
29550002 |
2018 |
|
Temporomandibular Joint Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Functional pain syndromes, such as fibromyalgia and temporomandibular disorder, are associated with enhanced catecholamine tone and decreased levels of catechol-O-methyltransferase (COMT; an enzyme that metabolizes catecholamines).
|
29935309 |
2018 |
|
Temporomandibular Joint Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain.
|
27792797 |
2017 |
|
Temporomandibular Joint Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Furthermore, a significant (P = 0.04) interaction of COMT diplotype and time-varying stress showed that a postbaseline increase of 1.0 standard deviation in PSS more than doubled risk of TMD incidence in subjects with low-activity COMT diplotypes (hazard ratio = 2.35; 95% confidence limits: 1.66, 3.32), an effect not found in subjects with high-activity COMT diplotypes (hazard ratio = 1.42; 95% confidence limits: 0.96, 2.09).
|
26198390 |
2015 |
|
Temporomandibular Joint Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Results show that the COMT rs4680 (rs4680;s4680;rs1200746244" genes_norm="1312;4524">val(158)met) polymorphism is most strongly associated with outcome measures, such that individuals with the minor A allele (met) exhibit reduced COMT activity, increased TMD risk, and increased musculoskeletal pain.
|
25218601 |
2014 |
|
Temporomandibular Joint Disorders
|
0.400 |
Biomarker
|
group |
CTD_human |
Results show that the COMT rs4680 (val(158)met) polymorphism is most strongly associated with outcome measures, such that individuals with the minor A allele (met) exhibit reduced COMT activity, increased TMD risk, and increased musculoskeletal pain.
|
25218601 |
2014 |
|
Temporomandibular Joint Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our data extend the number of SNPs present in the promoter region that could play a regulatory role in COMT gene and suggest that the genetic polymorphisms rs 165656 and rs 4646310 exert a role in TMD susceptibility.
|
23446089 |
2014 |
|
Temporomandibular Joint Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Cross-sectional data from the population-based Study of Health in Pomerania (SHIP) in Germany were used to estimate additive interactions between depressive symptoms and 22 single-nucleotide polymorphisms (SNPs) of the COMT gene and the neighbouring thioredoxin reductase 2 (TXNRD2) gene on TMD pain.
|
22337325 |
2012 |
|
Temporomandibular Joint Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The OPPERA findings provided evidence supporting previously reported associations between TMD and 2 genes: HTR2A and COMT.
|
22074755 |
2011 |
|
Temporomandibular Joint Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Forty Caucasian female participants meeting the Research Diagnostic Criteria for TMD were genotyped for COMT polymorphisms and completed a randomized, double-blind, placebo-controlled, two-period crossover pilot study.
|
20216107 |
2010 |
|
Temporomandibular Joint Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Recently, our group demonstrated that three common haplotypes of the human COMT gene, divergent in two synonymous and one nonsynonymous position, are associated with experimental pain sensitivity and onset of temporomandibular joint disorder.
|
20336436 |
2010 |
|
Temporomandibular Joint Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder.
|
20974455 |
2010 |
|
Temporomandibular Joint Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Psychological factors linked to pain sensitivity influenced TMD risk independently of the effects of the COMT haplotype on TMD risk.
|
17959908 |
2007 |