|
Attention deficit hyperactivity disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Currently, peripheral COMT inhibitors have an important role in the treatment of Parkinson's disease, and central COMT inhibitors have a potential role in the treatment of various neuropsychiatric disorders, such as attention deficit hyperactivity disorder.
|
30685433 |
2019 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Thus, our findings may help to improve the understanding of the neuroanatomic basis for the relationship between the COMT genotype and ADHD pathogenesis.
|
30508034 |
2019 |
|
Attention deficit hyperactivity disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
We examined 4 SNPs located on genes previously associated to dyslexia (KIAA0319, DCDC2, DYX1C1 and FOXP2) and 3 SNPs within genes related to ADHD (COMT, MAOA and DBH) in a cohort of Spanish children (N = 2078) that met the criteria of having one, both or none of these disorders (dyslexia and ADHD).
|
30379906 |
2018 |
|
Attention deficit hyperactivity disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
For CpG sites at genes of the dopaminergic (COMT, ANKK1) and the neurotrophic (BDNF, NGFR) system, associations with the Nogo-P3 as well as ADHD symptom severity were found suggesting that these systems are involved in response control deficits in ADHD.
|
28630479 |
2017 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
COMT Val158Met genotype data were also obtained from children with ADHD.
|
28687733 |
2017 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Contrasting with previous findings in Caucasians, the COMT Met allele was associated with striatal GMV alterations in Japanese children with ADHD.
|
26576742 |
2017 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to assess the role of the catechol-O-methyltransferase (<i>COMT</i>) and of the dopamine transporter (<i>DAT1</i>) genes on ADHD symptoms in the general population.
|
27327562 |
2016 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
COMT Val158Met (rs4680) may have divergent effect on working memory in ADHD children compared with healthy controls.
|
26560848 |
2016 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to derive a comprehensive, whole-brain characterization of large-scale axonal connectivity differences in attention-deficit/hyperactivity disorder (ADHD) associated with catechol-O-methyltransferase gene (COMT) Val158Met polymorphism.
|
25201318 |
2015 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Structural correlates of COMT Val158Met polymorphism in childhood ADHD: a voxel-based morphometry study.
|
25495556 |
2015 |
|
Attention deficit hyperactivity disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Among the most commonly investigated candidate genes for ADHD are DRD2, SLC6A3 (DAT), COMT and MAOA.
|
24942140 |
2014 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results showed a lack of association between the COMT Val/Val genotype and ADHD in Japan.
|
24035255 |
2014 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Although the reported nominally significant associations did not stay significant after correcting for multiple testing, our results support previous findings about the possible involvement of the COMT (Val(158)-Met) polymorphism in the treatment response to methylphenidate in children with ADHD.
|
24763183 |
2014 |
|
Attention deficit hyperactivity disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
We summarized the reported findings investigating associations between COMT gene and ADHD and performed a meta-analysis of previous studies to assess the overall magnitude and significance of the association.
|
23907791 |
2014 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
On the other hand, there was no significant association between the SNAP-25 (rs1051312), NTF3 (rs6332), or COMT (rs4818) gene polymorphisms and ADHD.
|
23872233 |
2013 |
|
Attention deficit hyperactivity disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Catechol O-methyltransferase (COMT) has been associated with aggression, attention deficit/hyperactivity disorder (ADHD), and other psychiatric disorders.
|
22972758 |
2013 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
One hundred seven methadone maintenance treatment patients, 36 having an ADHD diagnosis, 176 adult patients with ADHD without SUDs, and 500 healthy controls were genotyped for variants in the DRD4 (exon 3 VNTR), DRD5 (upstream VNTR), HTR1B (rs6296), DBH (rs2519152), COMT (rs4680; rs4680;s4680" genes_norm="1312;4988">Val158Met), and OPRM1 (rs1799971; 118A>G) genes.
|
22841130 |
2013 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We have assessed variants in four genes, DDC (rs3837091 and rs3735273), DRD2 (rs1800496, rs1801028, and rs1799732), DRD4 (rs4646984 and rs4646983), and COMT (rs165599 and rs740603) in Indian ADHD subjects with comorbid attributes.
|
24163823 |
2013 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Catechol-O-methyltransferase (COMT; Val158Met) and DA D4-receptor (DRD4; 48 bp VNTR) genotypes were analyzed for effects on behavioral and neural correlates of prefrontal response control (NoGo-anteriorization, NGA) using a Go-NoGo task and electroencephalography (114 controls and 181 patients with attention-deficit/hyperactivity disorder).
|
22617852 |
2013 |
|
Attention deficit hyperactivity disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our findings replicate previous results and suggest a role for COMT in the etiology of DBD in children and adolescents with ADHD.
|
22270685 |
2012 |
|
Attention deficit hyperactivity disorder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Based on this information we evaluated the contribution to ADHD of nine genes involved in dopaminergic neurotransmission (DRD1, DRD2, DRD3, DRD4, DRD5, DAT1, TH, DBH and COMT).
|
22404661 |
2012 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results suggest an effect of the COMT genotype on the trajectory of oppositional defiant disorder symptoms improvement with MPH treatment in boys with ADHD.
|
21550019 |
2011 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To replicate the association between COMT genotype and antisocial behavior in ADHD and to then test whether (1) impaired executive control or (2) impaired social understanding act as intermediate phenotypes for this association and lie on the risk pathway between COMT genotype and antisocial behavior.
|
21135332 |
2010 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Attention-deficit/hyperactivity disorder phenotype is influenced by a functional catechol-O-methyltransferase variant.
|
19946713 |
2010 |
|
Attention deficit hyperactivity disorder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study tested whether variation in three polymorphisms of the COMT gene was predictive of symptoms of conduct disorder and ADHD, in a sample of 174 incarcerated Russian adolescent male delinquents.
|
19997043 |
2010 |