COMT, catechol-O-methyltransferase, 1312

N. diseases: 622; N. variants: 47
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE Several promising genes, such as the COMT (catechol-O-methyltransferase) gene, the serotonin transporter gene (SLC6A4), and neuropeptide Y (NPY) suggest gene × environment interaction between genetic variants, childhood adversity, and the occurrence of PTSD and MDD, indicating an impact of these genes on resilience. 31583809 2020
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE Expressions of NMDAR-related genes including SRR, SHMT2, PSAT1, GCAT, GAD1, SLC1A4, NRG1 and COMT in peripheral WBCs of 110 patients with MDD (25 drug-naïve, 21 drug-free, and 64 medicated patients) and 125 healthy individuals were measured using quantitative PCR. 30699855 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE We have prospectively demonstrated the relationship between the single-nucleotide polymorphism of the Val158Met COMT gene (rs4680) and the hippocampal subfields in drug-naive MDD patients. 31239688 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE A gender-specific COMT haplotype contributes to risk modulation rather than disease severity of major depressive disorder in a Chinese population. 30597299 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression. 31721892 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 PosttranslationalModification disease BEFREE COMT gene methylation has a substantial effect on the prefrontal connectivity in patients with MDD. 29723539 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE Further post-hoc tests showed a nonlinear modulation effect of COMT on gFCD in the development of MDD. 28728097 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE To overcome the problem of poor sample size detecting genes of small effect, we perform a meta-analysis of the current literature, investigating the influence of the COMT Val158Met polymorphism on the pathogenesis of MDD, with a major focus on the effect of gender. 26813412 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE The current study is a preliminary investigation of the association of polymorphisms of the serotonin transporter (SLC6A4), dopamine transporter (DAT1), dopamine receptor D4 (DRD4), and catechol-O-methyl transferase (COMT) genes with theory of mind decoding in a sample of adults with major depression. 26974654 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE Our aim was to assess the effect of accumulation of specific SERT, BDNF and COMT gene functional polymorphisms on brain structure in MDD patients. 26956059 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE Together, our results indicate that the COMT Val158Met polymorphism is a vulnerability factor for MDD with distinct effects in different ethnic populations. 26803486 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE A total of 26 outpatients with treatment-resistant MDD and 27 matched healthy controls underwent magnetic resonance imaging and genotyping for six SNPs in monoaminergic genes [serotonin transporter (SLC6A4), norepinephrine transporter (SLC6A2), serotonin 1A and 2A receptors (HTR1A and HTR2A), catechol-O-methyltransferase (COMT), and brain-derived neurotrophic factor (BDNF)]. 25990886 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease PSYGENET Genotyping for COMT polymorphisms was carried out by DNA direct sequencing in 112 patients (54 MDD and 58 BD) and 58 healthy subjects. 25766270 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE rs4680 in COMT and rs3219151 in GABRA6 showed positive associations with PD and MDD. 25974322 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE Moreover this genotype resulted in epistasis with COMT Met carriers in association with MDD. 26021967 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE The authors prospectively investigated the relationship between the Val108/158Met COMT genotype and voxel-based morphometry (VBM) findings for patients with first-episode and treatment-naïve MDD and healthy subjects (HS). 26253436 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE Genotyping for COMT polymorphisms was carried out by DNA direct sequencing in 112 patients (54 MDD and 58 BD) and 58 healthy subjects. 25766270 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease PSYGENET In this study, we investigate the association of COMT/MTHFR and their interactions with MDD and antidepressant response in Chinese Han population. 24751310 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE Sixteen SNPs in the COMT gene were investigated in 123 outpatients with major depression. 24814141 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease PSYGENET Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical outcomes in patients with major depression. 24555772 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical outcomes in patients with major depression. 24555772 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE In this study, we investigate the association of COMT/MTHFR and their interactions with MDD and antidepressant response in Chinese Han population. 24751310 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE Catechol-O-methyltransferase genotype as modifier of superior responses to venlafaxine treatment in major depressive disorder. 23706899 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease PSYGENET Catechol-O-methyltransferase genotype as modifier of superior responses to venlafaxine treatment in major depressive disorder. 23706899 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE The goal of our work is to study the possible effect of clinical variables, neuropsychological performance, and the 5HTTLPR, the rs25531 of the SLC6A4 gene, and the val108/58Met of the COMT gene polymorphisms on the prediction of the speed of remission in MDD patients. 23787408 2013