Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
KLF6 IVS 1-27 G > A may not be associated with cancer susceptibility, especially the susceptibility of unselected prostate cancer.
|
29970714 |
2018 |
Prostate carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Klf6 protein levels significantly decreased with progression in the TRAMP model of prostate cancer (P < 0.05), but there was no difference in Klf6 promoter methylation.
|
22782870 |
2013 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer.
|
23219426 |
2013 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study investigated the prevalence and significance of KLF6 exon 2 mutations and splice variants (SVs) in different stages of human PC progression.
|
22819534 |
2012 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, a common germline polymorphism in the KLF6 gene associated with increased prostate cancer risk in a large multi-institutional study of 3411 men results in increased expression of KLF6-SV1.
|
19097929 |
2009 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study strongly supports the notion that KLF6 and TP53 mutations are not frequent events in prostate cancer.
|
19020536 |
2008 |
Prostate carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis.
|
18596922 |
2008 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study proposes that variation at putative 8q24 cis-regulator(s) of transcription can significantly alter germline c-MYC expression levels and, thus, contribute to prostate cancer susceptibility by down-regulating the prostate tumor suppressor KLF6 gene.
|
18190704 |
2008 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, we therefore introduced wtKLF6 gene into a prostatic carcinoma derived cell line, DU145, and a renal carcinoma derived cell line, OS-RC-2, and have established DU145-KLF6 and OS-RC-2-KLF6 cell lines, both of which stably over-express KLF6.
|
18719336 |
2008 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results do not support the suggested association of KLF6 IVS1 -27G>A germline polymorphism with pCA risk and also suggest that the variant is not a risk allele for BPH in the Finnish population.
|
17125911 |
2007 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The rs3750861 affects expression of KLF6 splicing variants in prostate cancer and we found that its rare allele is associated with reduced lung cancer risk (odds ratio, 0.5; 95% CI, 0.3-0.8).
|
17223258 |
2007 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These include the ELAC2 (HPC2), MSR1, and RNASEL (HPC1) genes that have germline mutations in familial prostate cancer; AR, ATBF1, EPHB2 (ERK), KLF6, mitochondria DNA, p53, PTEN, and RAS that have somatic mutations in sporadic prostate cancer; AR, BRCA1, BRCA2, CHEK2 (RAD53), CYP17, CYP1B1, CYP3A4, GSTM1, GSTP1, GSTT1, PON1, SRD5A2, and VDR that have germline genetic variants associated with either hereditary and/or sporadic prostate cancer; and ANXA7 (ANX7), KLF5, NKX3-1 (NKX3.1), CDKN1B (p27), and MYC that have genomic copy number changes affecting gene function.
|
16267836 |
2006 |
Prostate carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PAC1-R null isoform expression in human prostate cancer tissue.
|
16372333 |
2006 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The negative association between KLF6 IVS1-27A and prostate cancer risk supports a population-specific effect of susceptibility alleles in prostate tumorigenesis.
|
16598737 |
2006 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These observations provide additional evidence for a role of PACAP and PAC1 R in the events determining the outcome of PCa.
|
16888207 |
2006 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we show that a germline KLF6 single nucleotide polymorphism, confirmed in a tri-institutional study of 3,411 men, is significantly associated with an increased relative risk of prostate cancer in men, regardless of family history of disease.
|
15735005 |
2005 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Most recently, we identified a common KLF6 germ line single nucleotide polymorphism that is associated with an increased relative risk of prostate cancer and the increased production of three alternatively spliced, dominant-negative KLF6 isoforms.
|
15994951 |
2005 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data indicate that acetylation may regulate KLF6 function, and its loss in some tumor-derived mutants could contribute to its failure to suppress growth in prostate cancer.
|
16230382 |
2005 |
Prostate carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Krüppel-like factor 6 (KLF6) is a ubiquitously expressed zinc finger transcriptional factor, which has been suggested to be a candidate tumor suppressor gene in prostate cancer and astrocytic glioma.
|
15172991 |
2004 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Kruppel-like factor 6 (KLF6) is a ubiquitous zinc finger tumor suppressor that is often mutated in prostate cancer.
|
15057748 |
2004 |
Prostate carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The Kruppel-like transcription factor KLF6 is a novel tumor-suppressor gene mutated in a significant fraction of human prostate cancer.
|
15064720 |
2004 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that KLF6 germ-line mutations are of marginal importance in prostate cancer predisposition in Finland.
|
15247715 |
2004 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, a candidate tumor suppressor gene, KLF6, which is mapped to chromosome 10p, was found to be frequently mutated in prostate cancer.
|
12740910 |
2003 |
Prostate carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression levels of KLF6 were significantly lost in 4 of 20 (20%) xenografts/cell lines of prostate cancer, as detected by RT-PCR and Northern blot analysis.
|
12651626 |
2003 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Whereas TP53 mutations typical of prostate cancer were found at a frequency consistent with the literature, no KLF6 mutations were found in any of the tumour samples nor in the three prostate cancer cell lines.
|
12915879 |
2003 |