Malignant neoplasm of stomach
|
0.660 |
AlteredExpression
|
disease |
BEFREE |
An inverse association was observed between miR‑18b and KLF6 mRNA levels in GC tissues.
|
30628682 |
2019 |
Malignant neoplasm of stomach
|
0.660 |
AlteredExpression
|
disease |
BEFREE |
In summary, these data suggest that KLF6 gene is a direct target of miR-181a and miR-181a functions as an oncomir in gastric cancer by repressing the expression of tumor suppressor KLF6.
|
22581522 |
2012 |
Malignant neoplasm of stomach
|
0.660 |
GeneticVariation
|
disease |
BEFREE |
A small interfering RNA targeting the KLF6 splice variant, KLF6-SV1, as gene therapy for gastric cancer.
|
21538018 |
2011 |
Malignant neoplasm of stomach
|
0.660 |
GeneticVariation
|
disease |
BEFREE |
Thus, in this Chinese population the KLF6 IVS1 -27AA genotype was associated with a decreased risk of gastric cancer and with cancer stage.
|
21309496 |
2011 |
Malignant neoplasm of stomach
|
0.660 |
GeneticVariation
|
disease |
BEFREE |
The IVS1 -27G/A polymorphism of KLF6 has been investigated, which can influence susceptibility to gastric cancer and disease outcome.
|
18190240 |
2008 |
Malignant neoplasm of stomach
|
0.660 |
GeneticVariation
|
disease |
BEFREE |
To determine whether genetic alterations of KLF6 gene are involved in the development and/or progression of gastric cancer, we have screened a set of 80 sporadic gastric cancers for mutations and allele loss of the KLF6 gene.
|
15824733 |
2005 |
Malignant neoplasm of stomach
|
0.660 |
Biomarker
|
disease |
HPO |
|
|
|
Malignant neoplasm of stomach
|
0.660 |
CausalMutation
|
disease |
CGI |
|
|
|
Malignant neoplasm of stomach
|
0.660 |
Biomarker
|
disease |
CTD_human |
|
|
|
Stomach Neoplasms
|
0.610 |
GeneticVariation
|
group |
LHGDN |
Genetic alterations of the KLF6 gene in gastric cancer.
|
15824733 |
2005 |
Stomach Neoplasms
|
0.610 |
CausalMutation
|
group |
CGI |
|
|
|
Stomach Neoplasms
|
0.610 |
CausalMutation
|
group |
CLINVAR |
|
|
|
Stomach Neoplasms
|
0.610 |
Biomarker
|
group |
CTD_human |
|
|
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
KLF6 IVS 1-27 G > A may not be associated with cancer susceptibility, especially the susceptibility of unselected prostate cancer.
|
29970714 |
2018 |
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer.
|
23219426 |
2013 |
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Klf6 protein levels significantly decreased with progression in the TRAMP model of prostate cancer (P < 0.05), but there was no difference in Klf6 promoter methylation.
|
22782870 |
2013 |
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study investigated the prevalence and significance of KLF6 exon 2 mutations and splice variants (SVs) in different stages of human PC progression.
|
22819534 |
2012 |
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In addition, a common germline polymorphism in the KLF6 gene associated with increased prostate cancer risk in a large multi-institutional study of 3411 men results in increased expression of KLF6-SV1.
|
19097929 |
2009 |
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis.
|
18596922 |
2008 |
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study strongly supports the notion that KLF6 and TP53 mutations are not frequent events in prostate cancer.
|
19020536 |
2008 |
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study proposes that variation at putative 8q24 cis-regulator(s) of transcription can significantly alter germline c-MYC expression levels and, thus, contribute to prostate cancer susceptibility by down-regulating the prostate tumor suppressor KLF6 gene.
|
18190704 |
2008 |
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
Kidney and prostate cancers are leading causes of death in the world, and accumulating evidence suggests that tumor suppressor gene, Krüppel-like factor 6 (KLF6), plays an important role in both the development and the progression of cancer.
|
18719336 |
2008 |
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The rs3750861 affects expression of KLF6 splicing variants in prostate cancer and we found that its rare allele is associated with reduced lung cancer risk (odds ratio, 0.5; 95% CI, 0.3-0.8).
|
17223258 |
2007 |
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results do not support the suggested association of KLF6 IVS1 -27G>A germline polymorphism with pCA risk and also suggest that the variant is not a risk allele for BPH in the Finnish population.
|
17125911 |
2007 |
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
PAC1-R null isoform expression in human prostate cancer tissue.
|
16372333 |
2006 |