ADORA2A, adenosine A2a receptor, 135

N. diseases: 213; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.390 Biomarker group BEFREE Altogether, the present findings suggested that the ADORA2A gene and the interaction of ADORA2A and DRD2 genes may play a role in anxiety disorders in children and adolescents with ADHD. 30946941 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.390 Biomarker group BEFREE CYP1A2 is responsible for the majority of the metabolism of caffeine, and ADORA2A has been linked to caffeine-induced anxiety. 30248915 2018
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.390 GeneticVariation group BEFREE Here, it was investigated whether the adenosine 2 A receptor gene (ADORA2A) 1976T/C (rs5751876) variant - previously associated with anxiety disorders and anxiety-related phenotypes as well as general attentional efficiency -was involved in the regulation of this network. 27262510 2016
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.390 Biomarker group BEFREE The present results point to an impaired ability to selectively process very early information and to gate irrelevant sensory information, respectively, in female ADORA2A 1976TT homozygotes in response to caffeine, providing further evidence for the adenosinergic system to be involved in the pathogenesis of anxiety. 22940476 2013
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.390 GeneticVariation group BEFREE Our data provide further support for an important role of ADORA2A variants in the pathogenesis of anxiety disorders and anxious personality reflecting their potential as basic susceptibility factors. 20334879 2010
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.390 GeneticVariation group BEFREE In addition, association of ADORA2A variants with anxiety was replicated for individuals with ASD. 19565319 2010
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.390 GeneticVariation group BEFREE Apart from the almost completely linked ADORA2A SNP rs3761422, no other of eight ADORA2A and seven ADORA1 SNPs studied were found to be clearly associated with effects of caffeine on anxiety, alertness, or headache. 20520601 2010
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.390 Biomarker group CTD_human Genetics of caffeine consumption and responses to caffeine. 20532872 2010
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.390 Biomarker group CTD_human Caffeine-induced anxiety (VAS) was also associated with two-loci interactions of selected ADORA2A and DRD2 polymorphisms. 18305461 2008
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.390 GeneticVariation group BEFREE Caffeine-induced anxiety (VAS) was also associated with two-loci interactions of selected ADORA2A and DRD2 polymorphisms. 18305461 2008
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.390 GeneticVariation group BEFREE Interindividual variation in anxiety response to amphetamine: possible role for adenosine A2A receptor gene variants. 16118787 2005
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.390 Biomarker group CTD_human Interindividual variation in anxiety response to amphetamine: possible role for adenosine A2A receptor gene variants. 16118787 2005
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.390 Biomarker group CTD_human Association between A2a receptor gene polymorphisms and caffeine-induced anxiety. 12825092 2003