ADORA2A, adenosine A2a receptor, 135

N. diseases: 213; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0917801
Disease: Sleeplessness
Sleeplessness
0.320 GeneticVariation phenotype BEFREE We found that at caffeine levels higher than 300 mg/day, total sleep time (TST) decreased (<i>F</i> = 13.9, <i>p</i> < 0.01), with an increase of insomnia (ORa [95%CI] = 1.5 [1.1-1.9]) and sleep complaints (ORa [95%CI] = 1.9 [1.1-3.3]), whatever the ADORA2A polymorphism. 31817803 2019
CUI: C0917801
Disease: Sleeplessness
Sleeplessness
0.320 Biomarker phenotype CTD_human Genetics of caffeine consumption and responses to caffeine. 20532872 2010
CUI: C0917801
Disease: Sleeplessness
Sleeplessness
0.320 GeneticVariation phenotype BEFREE Here we show in humans that (1) habitual caffeine consumption is associated with reduced sleep quality in self-rated caffeine-sensitive individuals, but not in caffeine-insensitive individuals; (2) the distribution of distinct c.1083T>C genotypes of the adenosine A2A receptor gene (ADORA2A) differs between caffeine-sensitive and -insensitive adults; and (3) the ADORA2A c.1083T>C genotype determines how closely the caffeine-induced changes in brain electrical activity during sleep resemble the alterations observed in patients with insomnia. 17329997 2007