Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024535
Disease: Malaria, Falciparum
Malaria, Falciparum
0.360 Biomarker disease BEFREE Human single nucleotide polymorphisms SNPs associated with Knops blood group system; carried by complement receptor 1 may be associated with the pathology of P. falciparum malaria, and susceptibility to disease. 24200236 2013
CUI: C0024535
Disease: Malaria, Falciparum
Malaria, Falciparum
0.360 Biomarker disease BEFREE Southeast Asian ovalocytosis (SAO), α(+)-thalassemia, and low expression of complement receptor 1 (CR1) have been associated with protection against severe Plasmodium falciparum malaria. 20889874 2010
CUI: C0024535
Disease: Malaria, Falciparum
Malaria, Falciparum
0.360 GeneticVariation disease BEFREE Complement receptor 1 (CR1/CD35) levels on erythrocytes and related CR1 polymorphisms have been associated with response to falciparum malaria in populations inhabiting malaria-endemic regions. 19480840 2009
CUI: C0024535
Disease: Malaria, Falciparum
Malaria, Falciparum
0.360 Biomarker disease BEFREE It has been hypothesized that the African alleles Sl2 and McCb of the Swain-Langley (Sl) and McCoy (McC) blood group antigens of the complement receptor 1 (CR1) may confer a survival advantage in the setting of Plasmodium falciparum malaria, but this has not been demonstrated. 16277654 2005
CUI: C0024535
Disease: Malaria, Falciparum
Malaria, Falciparum
0.360 GeneticVariation disease BEFREE The Knops blood group antigen erythrocyte polymorphisms have been associated with reduced falciparum malaria-based in vitro rosette formation (putative malaria virulence factor). 12847553 2003
CUI: C0024535
Disease: Malaria, Falciparum
Malaria, Falciparum
0.360 Biomarker disease CTD_human Localization of Knops system antigens in the long homologous repeats of complement receptor 1. 11724985 2001
CUI: C0024535
Disease: Malaria, Falciparum
Malaria, Falciparum
0.360 GeneticVariation disease BEFREE To investigate the relationship between CR1 density polymorphism and disease severity, we typed 185 Thai patients with acute falciparum malaria (55 severe and 130 uncomplicated) for their genotypes of this polymorphism. 11425154 2001
CUI: C0024535
Disease: Malaria, Falciparum
Malaria, Falciparum
0.360 Biomarker disease CTD_human P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1. 9230440 1997