Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020179
Disease: Huntington Disease
Huntington Disease
0.270 AlteredExpression disease BEFREE To examine the effectiveness of βL on HD, βL was orally applied to R6/2 HD mice and behavioral phenotypes associated with HD, such as impairment of rota-rod performance and increase of clasping behavior, as well as changes of Sirt1 expression, CREB phosphorylation and PGC-1α deacetylation were examined. 29742127 2018
CUI: C0020179
Disease: Huntington Disease
Huntington Disease
0.270 AlteredExpression disease BEFREE Alongside this, gene expression of transcription factors (Zfp516 and Pparα), important inducers of WAT browning, were increased in R6/2 inguinal WAT, and Creb1 was highlighted as a key transcription factor in HD. 27486903 2016
CUI: C0020179
Disease: Huntington Disease
Huntington Disease
0.270 AlteredExpression disease BEFREE Elevated PKA/CREB activity in healthy flies produces patterns of sleep and activity similar to those in our HD models. 26604145 2016
CUI: C0020179
Disease: Huntington Disease
Huntington Disease
0.270 Biomarker disease BEFREE Research has increasingly focused on the role of the cyclic adenosine monophosphate (cAMP) response element binding (CREB) protein in learning and memory, particularly its role in cognitive disorders and neurodegeneration, such as Huntington's disease, Alzheimer's disease, Rubinstein-Taybi syndrome, and Coffin-Lowry syndrome. 23844928 2014
CUI: C0020179
Disease: Huntington Disease
Huntington Disease
0.270 Biomarker disease BEFREE In conclusion, ASCs-E delayed disease progression in animal model of HD by restoring of CREB-PGC1α pathway and could be a potential resource for treatment of HD. 23565152 2013
CUI: C0020179
Disease: Huntington Disease
Huntington Disease
0.270 Biomarker disease BEFREE Though loss of function in CBP/p300, a family of CREB-binding proteins, has been causally associated with a variety of human neurological disorders, such as Rubinstein-Taybi syndrome, Huntington's disease and drug addiction, the role of EP300 interacting inhibitor of differentiation 1 (EID1), a CBP/p300 inhibitory protein, in modulating neurological functions remains completely unknown. 22186421 2012
CUI: C0020179
Disease: Huntington Disease
Huntington Disease
0.270 AlteredExpression disease BEFREE In the present studies, we investigated the role of Transducers of Regulated cAMP response element-binding (CREB) protein activity (TORCs) in HD, since TORCs play an important role in the expression of the transcriptional co-regulator peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), whose expression is impaired in HD. 22589249 2012
CUI: C0020179
Disease: Huntington Disease
Huntington Disease
0.270 Biomarker disease RGD Striatal modulation of cAMP-response-element-binding protein (CREB) after excitotoxic lesions: implications with neuronal vulnerability in Huntington's disease. 16420411 2006