|
Cocaine Dependence
|
0.510 |
Biomarker
|
disease |
CTD_human |
Evidence for beta1-adrenergic receptor involvement in amygdalar corticotropin-releasing factor gene expression: implications for cocaine withdrawal.
|
18596687 |
2009 |
|
Cocaine Dependence
|
0.510 |
Biomarker
|
disease |
PSYGENET |
We found that a single nucleotide polymorphism in the CAMK4 promoter was significantly associated with cocaine addiction, whereas variations in the CREB promoter regions did not correlate with drug abuse.
|
19001277 |
2008 |
|
Cocaine Dependence
|
0.510 |
GeneticVariation
|
disease |
BEFREE |
To test the relevance of these observations for addiction in humans, we performed an association study of CAMK4 and CREB promoter polymorphisms with cocaine addiction in a large sample of addicts.
|
19001277 |
2008 |
|
Cocaine Dependence
|
0.510 |
Biomarker
|
disease |
CTD_human |
Antisense-induced reduction in nucleus accumbens cyclic AMP response element binding protein attenuates cocaine reinforcement.
|
16359811 |
2006 |
|
Cocaine Dependence
|
0.510 |
Biomarker
|
disease |
CTD_human |
Different requirements for cAMP response element binding protein in positive and negative reinforcing properties of drugs of abuse.
|
11717377 |
2001 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
CREB regulates thousands of genes, yet to date, only a handful that mediate depression or antidepressant response have been identified as relevant CREB targets.
|
31255680 |
2019 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
CREB regulates thousands of genes, yet to date, only a handful that mediate depression or antidepressant response have been identified as relevant CREB targets.
|
31255680 |
2019 |
|
Neoplasm Metastasis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Long noncoding FOXD2-AS1 is activated by CREB1 and promotes cell proliferation and metastasis in glioma by sponging miR-185 through targeting AKT1.
|
30553445 |
2019 |
|
Neoplasm Metastasis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, cAMP responsive element binding protein 1 (CREB1) was identified as a direct and functional target of miR-520b, and GATA6 could suppress GC cell migration and metastasis via miR-520b-mediated repression of CREB1.
|
30674866 |
2019 |
|
Histiocytoma, Angiomatoid Fibrous
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Angiomatoid fibrous histiocytoma (AFH) is a rarely metastasizing neoplasm that typically occurs in the deep dermis and subcutis of the extremities of young patients, characterized by a t(2;22) translocation involving EWSR1 and CREB1.
|
31652145 |
2019 |
|
Histiocytoma, Angiomatoid Fibrous
|
0.400 |
Biomarker
|
disease |
BEFREE |
These cases suggested a closer relationship between angiomatoid fibrous histiocytoma and a recently proposed novel group of myxoid tumors with CREB family fusions.
|
31305268 |
2019 |
|
Histiocytoma, Angiomatoid Fibrous
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This review addresses three main neoplastic categories that are associated with specific paraneoplastic phenomena: (1) neoplasms having in common the presence of diffuse mixed inflammatory infiltration (closely simulating an inflammatory pseudotumor) and frequently associated with constitutional symptoms; (2) neoplasms with undifferentiated, anaplastic or rhabdoid cell morphology (frequently SWI/SNF-deficient) associated with diverse paraneoplastic manifestations; and (3) paraneoplasia associated with neoplasms carrying specific gene fusions such as solitary fibrous tumor (STAT6-NAB2 gene fusions), infantile fibrosarcoma and congenital mesoblastic nephroma (ETV6-NTRK3 gene fusions), and angiomatoid fibrous histiocytoma (EWSR1-CREB1 & EWSR1-ATF1 fusions).
|
30819530 |
2019 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling.
|
29722134 |
2018 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling.
|
29722134 |
2018 |
|
Neoplasm Metastasis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
A CREB1/miR-433 reciprocal feedback loop modulates proliferation and metastasis in colorectal cancer.
|
30523220 |
2018 |
|
Neoplasm Metastasis
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Elevated cyclic AMP levels promote BRAFCA/Pten-/- mouse melanoma growth but pCREB is negatively correlated with human melanoma progression.
|
29179997 |
2018 |
|
Histiocytoma, Angiomatoid Fibrous
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor that has been associated with EWSR1-CREB1 gene fusion.
|
29932283 |
2018 |
|
Histiocytoma, Angiomatoid Fibrous
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Intracranial myxoid mesenchymal tumors with EWSR1-CREB family gene fusions: myxoid variant of angiomatoid fibrous histiocytoma or novel entity?
|
28281318 |
2018 |
|
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The present study investigated the role of genetic variants in the 10 neurotrophic-related genes (BDNF, NGFR, NTRK2, MTOR, VEGFA, S100A10, SERPINE1, ARHGAP33, GSK3B, CREB1) in MDD susceptibility through a case-control (455 MDD patients and 2,998 healthy controls) study and in antidepressant efficacy (n = 455).
|
29725086 |
2018 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
PDE4 cyclic nucleotide phosphodiesterases regulate 3', 5' cAMP abundance in the CNS and thereby regulate PKA activity and phosphorylation of CREB, which has been implicated in learning and memory, depression and other functions.
|
29197324 |
2017 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
PDE4 cyclic nucleotide phosphodiesterases regulate 3', 5' cAMP abundance in the CNS and thereby regulate PKA activity and phosphorylation of CREB, which has been implicated in learning and memory, depression and other functions.
|
29197324 |
2017 |
|
Neoplasm Metastasis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
MetaLnc9 also interacted with P54nrb/NonO (NONO) to help mediate the activity of CRTC, a coactivator for the transcription factor CREB, reinforcing a positive feedback loop for metastasis.
|
28923857 |
2017 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
One GNB3 polymorphism (rs5443) and four CREB1 polymorphisms (rs2253206, rs2551941, rs6740584, rs11904814) were investigated based on known associations with MD.
|
28225778 |
2017 |
|
Histiocytoma, Angiomatoid Fibrous
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recurrent gene fusions involving EWSR1 with members of the cAMP response element binding protein (CREB) family (ATF1 and CREB1) have been reported in a diverse group of tumors including angiomatoid fibrous histiocytoma (AFH), soft tissue and gastrointestinal clear cell sarcoma, primary pulmonary myxoid sarcoma, and hyalinizing clear cell carcinoma of salivary gland.
|
28009602 |
2017 |
|
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
One GNB3 polymorphism (rs5443) and four CREB1 polymorphisms (rs2253206, rs2551941, rs6740584, rs11904814) were investigated based on known associations with MD.
|
28225778 |
2017 |