CREM, cAMP responsive element modulator, 1390

N. diseases: 100; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.030 AlteredExpression disease BEFREE Importantly, overexpression of PP2A reversed the adverse effects of chronic hyperglycemia and successfully restored the transient activation of CREB and ICER. 22509362 2012
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.030 AlteredExpression disease BEFREE We propose that induction of inappropriate ICER levels lead to defects in the secretory process of pancreatic beta-cells possibly contributing, in conjunction with other known deleterious effects of hyperglycemia, to defective insulin release in type 2 diabetes. 16498408 2006
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.030 Biomarker disease BEFREE Although ICER Igamma transgenic mice exhibit extremely high blood glucose levels throughout their lives, they survive long enough to develop diabetic nephropathy. 16049320 2005