Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Pexacerfont is a corticotropin-releasing factor subtype 1 receptor antagonist that was developed for the treatment of anxiety- and stress-related disorders.
|
30760067 |
2020 |
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Together, these data suggest that withdrawal from chronic ethanol dysregulates local CRF-GABAergic microcircuit to inhibit anxiolytic outputs of the BNST which may contribute to enhanced anxiety during alcohol withdrawal and drive alcohol-seeking behavior.
|
31494142 |
2020 |
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Although negative affect mediated in part by corticotropin-releasing factor (CRF) is a strong motivator for alcohol consumption in adults, comparisons of alcohol withdrawal in adolescents and adults generally have not included CRF-related measures such as anxiety.
|
30566247 |
2019 |
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Corticotropin releasing factor (CRF) is a key component of stress responsivity, modulating related behaviors including anxiety and reward.
|
30266597 |
2019 |
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Corticotropin-releasing factor binds with high affinity to CRF receptor 1 (CRFR1) and is implicated in stress-related mood disorders such as anxiety and depression.
|
30499109 |
2019 |
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
VacA causes anorexia and anxiety through the intracellular PLC-PKC pathway, migrates across the blood-brain barrier, and activates the Ucn1-CRF receptor axis.
|
30979915 |
2019 |
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Our findings identify a CRF<sup>CeA</sup>→CRF<sup>dlBST</sup> circuit for generating anxiety-like behavior and provide mechanistic support for recent human and primate data suggesting that the CeA and BST act together to generate states of anxiety.<b>SIGNIFICANCE STATEMENT</b> Anxiety is a negative emotional state critical to survival, but persistent, exaggerated apprehension causes substantial morbidity.
|
30530860 |
2019 |
Anxiety Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
EA and MB were able to regulate the concentration of CRH in serum and protein expression in the peripheral and central at different levels and promote the recovery of the HPA axis that may be the basis for EA and MB to improve colonic pathology and alleviate anxiety behavior in DSS-induced colitis.
|
30881446 |
2019 |
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Oxytocin facilitates adaptive fear and attenuates anxiety responses in animal models and human studies-potential interaction with the corticotropin-releasing factor (CRF) system in the bed nucleus of the stria terminalis (BNST).
|
30054732 |
2019 |
Anxiety Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The activation of CeA CRH neurons increased the anxiety-like behavior in Elevated-O maze (O-maze) and Light-Dark box (LDB).
|
30170157 |
2018 |
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety.
|
29786085 |
2018 |
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Maternal behavior and anxiety are potently modulated by the brain corticotropin-releasing factor (CRF) system postpartum.
|
29477300 |
2018 |
Anxiety Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
As an example, CRF altered correlations involving the dorsal raphe in males and the bed nucleus of the stria terminalis in females, suggesting sex differences in stress-activated circuits controlling mood and anxiety.
|
29037972 |
2018 |
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Further exploration of mechanisms by which endogenous OT system is modulated by CRF peptide family is needed to better understand the role of these neuropeptides in the regulation of anxiety and the stress response.
|
29618970 |
2018 |
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
We focus our efforts on describing CRF modulation of biogenic amine neuron populations that have widespread projections to the forebrain to modulate behaviors, including alcohol and drug intake, stress reactivity, and anxiety.
|
30217435 |
2018 |
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The results show that blockade of CRF<sub>1</sub> and CRF<sub>2</sub> receptors in the BLA and CeA produces a decrease in fear and/or anxiety, as suggested by a decrease in TI duration in the guinea pigs.
|
29246866 |
2018 |
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
A post-AESZS infusion of CRF into the CeA abolished the attenuation of anxiety by AESZS and 180 mg/kg/d AESZS suppressed NicW-induced increases in norepinephrine and 3-methoxy-4-hydroxy-phenylglycol levels in the CeA.
|
30245730 |
2018 |
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Corticotropin releasing factor (CRF) receptors belong to the secretin family of G proteincoupled receptors (GPCRs) and are responsible for initiating endocrine stress responses and mediating anxiety related behaviors upon activation via stressors.
|
28103782 |
2017 |
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
This paper explores the interactions of glucocorticoids and CRH in the presentation of anxiety and depressive disorders in an effort to better describe their differing roles in each of these clinical presentations.
|
28119322 |
2017 |
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Both cortisol and CRH have behavioral effects, and hypothalamic CRH hypersecretion has been associated with chronic states of anxiety and depression.
|
28500827 |
2017 |
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Plasma ACTH concentration was significantly increased by both administration routes of CRF; however, hyperlocomotion and anxiety behavior were induced only by the i.c.v. administration.
|
28689880 |
2017 |
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The results reveal that deletion of Dlk2 increased anxiety and depressive-like behaviors and altered the vulnerability to restraint stress on Crh gene expression in the PVN, Nr3c1 and Fkbp5 gene expression in the HIPP, and Hes1, Hes5 and Hey1 gene expression in the PVN, HIPP and AMY.
|
28863347 |
2017 |
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
We document the potential relevance of CRF peptide antagonists to reinvigorate stress/anxiety affected "anatomy systems" in order to boost their efficacy.
|
28103781 |
2017 |
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice.
|
27595593 |
2017 |
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Preclinical studies have shown that dysregulation of the corticotropin releasing factor (CRF) neurotransmission has been implicated in stress-related psychopathologies such as depression and anxiety, and may affect alcohol consumption.
|
29118713 |
2017 |