CRH, corticotropin releasing hormone, 1392

N. diseases: 402; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Pexacerfont is a corticotropin-releasing factor subtype 1 receptor antagonist that was developed for the treatment of anxiety- and stress-related disorders. 30760067 2020
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Together, these data suggest that withdrawal from chronic ethanol dysregulates local CRF-GABAergic microcircuit to inhibit anxiolytic outputs of the BNST which may contribute to enhanced anxiety during alcohol withdrawal and drive alcohol-seeking behavior. 31494142 2020
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Although negative affect mediated in part by corticotropin-releasing factor (CRF) is a strong motivator for alcohol consumption in adults, comparisons of alcohol withdrawal in adolescents and adults generally have not included CRF-related measures such as anxiety. 30566247 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Corticotropin releasing factor (CRF) is a key component of stress responsivity, modulating related behaviors including anxiety and reward. 30266597 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Corticotropin-releasing factor binds with high affinity to CRF receptor 1 (CRFR1) and is implicated in stress-related mood disorders such as anxiety and depression. 30499109 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE VacA causes anorexia and anxiety through the intracellular PLC-PKC pathway, migrates across the blood-brain barrier, and activates the Ucn1-CRF receptor axis. 30979915 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Our findings identify a CRF<sup>CeA</sup>→CRF<sup>dlBST</sup> circuit for generating anxiety-like behavior and provide mechanistic support for recent human and primate data suggesting that the CeA and BST act together to generate states of anxiety.<b>SIGNIFICANCE STATEMENT</b> Anxiety is a negative emotional state critical to survival, but persistent, exaggerated apprehension causes substantial morbidity. 30530860 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 AlteredExpression group BEFREE EA and MB were able to regulate the concentration of CRH in serum and protein expression in the peripheral and central at different levels and promote the recovery of the HPA axis that may be the basis for EA and MB to improve colonic pathology and alleviate anxiety behavior in DSS-induced colitis. 30881446 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Oxytocin facilitates adaptive fear and attenuates anxiety responses in animal models and human studies-potential interaction with the corticotropin-releasing factor (CRF) system in the bed nucleus of the stria terminalis (BNST). 30054732 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 AlteredExpression group BEFREE The activation of CeA CRH neurons increased the anxiety-like behavior in Elevated-O maze (O-maze) and Light-Dark box (LDB). 30170157 2018
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety. 29786085 2018
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Maternal behavior and anxiety are potently modulated by the brain corticotropin-releasing factor (CRF) system postpartum. 29477300 2018
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 AlteredExpression group BEFREE As an example, CRF altered correlations involving the dorsal raphe in males and the bed nucleus of the stria terminalis in females, suggesting sex differences in stress-activated circuits controlling mood and anxiety. 29037972 2018
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Further exploration of mechanisms by which endogenous OT system is modulated by CRF peptide family is needed to better understand the role of these neuropeptides in the regulation of anxiety and the stress response. 29618970 2018
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE We focus our efforts on describing CRF modulation of biogenic amine neuron populations that have widespread projections to the forebrain to modulate behaviors, including alcohol and drug intake, stress reactivity, and anxiety. 30217435 2018
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE The results show that blockade of CRF<sub>1</sub> and CRF<sub>2</sub> receptors in the BLA and CeA produces a decrease in fear and/or anxiety, as suggested by a decrease in TI duration in the guinea pigs. 29246866 2018
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE A post-AESZS infusion of CRF into the CeA abolished the attenuation of anxiety by AESZS and 180 mg/kg/d AESZS suppressed NicW-induced increases in norepinephrine and 3-methoxy-4-hydroxy-phenylglycol levels in the CeA. 30245730 2018
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Corticotropin releasing factor (CRF) receptors belong to the secretin family of G proteincoupled receptors (GPCRs) and are responsible for initiating endocrine stress responses and mediating anxiety related behaviors upon activation via stressors. 28103782 2017
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE This paper explores the interactions of glucocorticoids and CRH in the presentation of anxiety and depressive disorders in an effort to better describe their differing roles in each of these clinical presentations. 28119322 2017
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Both cortisol and CRH have behavioral effects, and hypothalamic CRH hypersecretion has been associated with chronic states of anxiety and depression. 28500827 2017
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Plasma ACTH concentration was significantly increased by both administration routes of CRF; however, hyperlocomotion and anxiety behavior were induced only by the i.c.v. administration. 28689880 2017
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE The results reveal that deletion of Dlk2 increased anxiety and depressive-like behaviors and altered the vulnerability to restraint stress on Crh gene expression in the PVN, Nr3c1 and Fkbp5 gene expression in the HIPP, and Hes1, Hes5 and Hey1 gene expression in the PVN, HIPP and AMY. 28863347 2017
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE We document the potential relevance of CRF peptide antagonists to reinvigorate stress/anxiety affected "anatomy systems" in order to boost their efficacy. 28103781 2017
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice. 27595593 2017
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.400 Biomarker group BEFREE Preclinical studies have shown that dysregulation of the corticotropin releasing factor (CRF) neurotransmission has been implicated in stress-related psychopathologies such as depression and anxiety, and may affect alcohol consumption. 29118713 2017