CRH, corticotropin releasing hormone, 1392

N. diseases: 402; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome
0.600 GeneticVariation disease BEFREE Ectopic cushing's syndrome due to corticotropin releasing hormone. 31041631 2019
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome
0.600 Biomarker disease BEFREE Thymic NET with CS exhibited stronger immunoreactivity for ACTH and CRH than those without CS. 30502716 2019
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome
0.600 Biomarker disease BEFREE ACTH = adrenocorticotropic hormone AUC = area under the curve CRH = corticotropin-releasing hormone CS = Cushing syndrome ECLIA = electrochemiluminescence immuno-assay LDDST = low-dose dexamethasone suppression test LNPC = late-night plasma cortisol LNSC = late-night salivary cortisol ONDST = overnight dexamethasone suppression test RIA = radio-immuno assay UFC = urinary free cortisol. 29144801 2018
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome
0.600 Biomarker disease BEFREE A retrospective cohort study, including children who underwent surgery due to CS (n = 115), was divided into children with a pituitary adenoma (Cushing disease) (n = 88), primary adrenal CS (n = 21), or ectopic adrenocorticotropin- or corticotropin-releasing hormone (ACTH-/CRH)-secreting tumors (n = 6). 28433999 2017
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome
0.600 GeneticVariation disease BEFREE We examined whether this relative hypercortisolism is associated with alterations in the pituitary-adrenocortical response to evening corticotropin-releasing hormone (CRH) stimulation. 28444400 2017
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome
0.600 Biomarker disease BEFREE ACTH = adrenocorticotropic hormone; BIPSS = bilateral inferior petrosal sinus sampling; CBG = corticosteroid-binding globulin; CD = Cushing disease; CRH = corticotropin-releasing hormone; CS = Cushing syndrome; Dex = dexamethasone; DST = dexamethasone suppression test; EAS = ectopic ACTH syndrome; FDA = U.S. Food & Drug Administration; HDDST = high-dose DST; IPS/P = inferior petrosal sinus to peripheral; MRI = magnetic resonance imaging; NET = neuroendocrine tumor; PET = positron emission tomography; UFC = urinary free cortisol. 28614036 2017
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome
0.600 Biomarker disease BEFREE Endogenous Cushing syndrome (CS) in pediatrics is rare; it may be caused by tumors that produce corticotropin in the pituitary gland or elsewhere, tumors that produce corticotropin-releasing hormone anywhere, and adrenocortical masses that produce cortisol. 27241967 2016
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome
0.600 Biomarker disease MGD ACTH secretion is stimulated by CRH, and we report a mouse model for Cushing's syndrome due to an N-ethyl-N-nitrosourea (ENU) induced Crh mutation at -120 bp of the promoter region, which significantly increased luciferase reporter activity and was thus a gain-of-function mutation. 24302625 2014
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome
0.600 Biomarker disease CTD_human We investigated whether the blockade of CRF receptors influences the development of hair loss in CRF over-expressing (OE)-mice that display phenotypes of Cushing's syndrome and chronic stress, including alopecia. 21359208 2011
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome
0.600 AlteredExpression disease BEFREE Hormonal challenge tests, such as the dexamethasone/corticotropin-releasing hormone test, have revealed elevated HPA activity (hypercortisolism) in at least a portion of patients with depression, although growing evidence has suggested that abnormally low HPA axis (hypocortisolism) has also been implicated in a variety of stress-related conditions. 20923424 2010
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome
0.600 Biomarker disease BEFREE To characterize somatostatin receptor status in vivo and ex vivo and immunoreactivity and gene transcription for proopiomelanocortin (POMC) and corticotropin-releasing hormone (CRH) in a case of Cushing's syndrome caused by a sporadic metastatic medullary thyroid carcinoma (MTC). 12053094 2002
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome
0.600 Biomarker disease BEFREE Finally, the finding of polyclonality in hyperplastic corticotroph tissue from a patient with an ectopic CRH-secreting tumor suggests there may be a more direct role for CRH in the pathogenesis of Cushing's syndrome in rare cases. 7805653 1994
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome
0.600 Biomarker disease BEFREE These findings indicate that chronic production of excess CRF results in sustained stimulation of pituitary corticotrope cells, resulting in elevated ACTH and consequent glucocorticoid overproduction, a condition that leads to the development of Cushing's syndrome. 1597149 1992