Cushing Syndrome
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Ectopic cushing's syndrome due to corticotropin releasing hormone.
|
31041631 |
2019 |
Cushing Syndrome
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thymic NET with CS exhibited stronger immunoreactivity for ACTH and CRH than those without CS.
|
30502716 |
2019 |
Cushing Syndrome
|
0.600 |
Biomarker
|
disease |
BEFREE |
ACTH = adrenocorticotropic hormone AUC = area under the curve CRH = corticotropin-releasing hormone CS = Cushing syndrome ECLIA = electrochemiluminescence immuno-assay LDDST = low-dose dexamethasone suppression test LNPC = late-night plasma cortisol LNSC = late-night salivary cortisol ONDST = overnight dexamethasone suppression test RIA = radio-immuno assay UFC = urinary free cortisol.
|
29144801 |
2018 |
Cushing Syndrome
|
0.600 |
Biomarker
|
disease |
BEFREE |
A retrospective cohort study, including children who underwent surgery due to CS (n = 115), was divided into children with a pituitary adenoma (Cushing disease) (n = 88), primary adrenal CS (n = 21), or ectopic adrenocorticotropin- or corticotropin-releasing hormone (ACTH-/CRH)-secreting tumors (n = 6).
|
28433999 |
2017 |
Cushing Syndrome
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We examined whether this relative hypercortisolism is associated with alterations in the pituitary-adrenocortical response to evening corticotropin-releasing hormone (CRH) stimulation.
|
28444400 |
2017 |
Cushing Syndrome
|
0.600 |
Biomarker
|
disease |
BEFREE |
ACTH = adrenocorticotropic hormone; BIPSS = bilateral inferior petrosal sinus sampling; CBG = corticosteroid-binding globulin; CD = Cushing disease; CRH = corticotropin-releasing hormone; CS = Cushing syndrome; Dex = dexamethasone; DST = dexamethasone suppression test; EAS = ectopic ACTH syndrome; FDA = U.S. Food & Drug Administration; HDDST = high-dose DST; IPS/P = inferior petrosal sinus to peripheral; MRI = magnetic resonance imaging; NET = neuroendocrine tumor; PET = positron emission tomography; UFC = urinary free cortisol.
|
28614036 |
2017 |
Cushing Syndrome
|
0.600 |
Biomarker
|
disease |
BEFREE |
Endogenous Cushing syndrome (CS) in pediatrics is rare; it may be caused by tumors that produce corticotropin in the pituitary gland or elsewhere, tumors that produce corticotropin-releasing hormone anywhere, and adrenocortical masses that produce cortisol.
|
27241967 |
2016 |
Cushing Syndrome
|
0.600 |
Biomarker
|
disease |
MGD |
ACTH secretion is stimulated by CRH, and we report a mouse model for Cushing's syndrome due to an N-ethyl-N-nitrosourea (ENU) induced Crh mutation at -120 bp of the promoter region, which significantly increased luciferase reporter activity and was thus a gain-of-function mutation.
|
24302625 |
2014 |
Cushing Syndrome
|
0.600 |
Biomarker
|
disease |
CTD_human |
We investigated whether the blockade of CRF receptors influences the development of hair loss in CRF over-expressing (OE)-mice that display phenotypes of Cushing's syndrome and chronic stress, including alopecia.
|
21359208 |
2011 |
Cushing Syndrome
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Hormonal challenge tests, such as the dexamethasone/corticotropin-releasing hormone test, have revealed elevated HPA activity (hypercortisolism) in at least a portion of patients with depression, although growing evidence has suggested that abnormally low HPA axis (hypocortisolism) has also been implicated in a variety of stress-related conditions.
|
20923424 |
2010 |
Cushing Syndrome
|
0.600 |
Biomarker
|
disease |
BEFREE |
To characterize somatostatin receptor status in vivo and ex vivo and immunoreactivity and gene transcription for proopiomelanocortin (POMC) and corticotropin-releasing hormone (CRH) in a case of Cushing's syndrome caused by a sporadic metastatic medullary thyroid carcinoma (MTC).
|
12053094 |
2002 |
Cushing Syndrome
|
0.600 |
Biomarker
|
disease |
BEFREE |
Finally, the finding of polyclonality in hyperplastic corticotroph tissue from a patient with an ectopic CRH-secreting tumor suggests there may be a more direct role for CRH in the pathogenesis of Cushing's syndrome in rare cases.
|
7805653 |
1994 |
Cushing Syndrome
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings indicate that chronic production of excess CRF results in sustained stimulation of pituitary corticotrope cells, resulting in elevated ACTH and consequent glucocorticoid overproduction, a condition that leads to the development of Cushing's syndrome.
|
1597149 |
1992 |