CRH, corticotropin releasing hormone, 1392

N. diseases: 402; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE TC-IBS showed a pronounced depression phenotype with increased corticotropin-releasing hormone receptor (CRHR)1 and CRHR2 expression at the frontal cortex and increased serum ACTH concentration. 31570003 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE Corticotropin-releasing factor binds with high affinity to CRF receptor 1 (CRFR1) and is implicated in stress-related mood disorders such as anxiety and depression. 30499109 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE Corticotropin-releasing factor (CRF) regulates stress responses, and aberrant CRF signals are associated with depressive disorders. 31017816 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE Specifically described are sex differences in receptors for the stress neuropeptide, corticotropin-releasing factor (CRF), that render the locus coeruleus arousal system of females more vulnerable to stress and less adaptable to CRF hypersecretion, a condition found in patients with PTSD and depression. 30022063 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE Hypothalamic insulin and glucagon-like peptide-1 levels in an animal model of depression and their effect on corticotropin-releasing hormone promoter gene activity in a hypothalamic cell line. 30831439 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE Studying the network of CRF and immune responses will help to enhance our understanding of the pathogenesis of depression. 31312123 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE Gross anatomical abnormalities (volume changes of the third ventricle, the hypothalamus, and its nuclei) and alterations at the cellular level (loss of neurons, increased or decreased expression of hypothalamic peptides such as oxytocin, vasopressin, corticotropin-releasing hormone, and other regulatory factors as well as of enzymes involved in neurotransmitter and neuropeptide metabolism) have been reported in schizophrenia and/or depression. 29767278 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE Dysregulation of the corticotropin-releasing hormone (CRH) system has been implicated in stress-related psychopathologies such as depression and anxiety. 31619956 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE Corticotropin-releasing hormone (CRH), produced by MCs, has been found in microglial cells where it regulates immune cells and contributes to the pathogenesis of neurodegenerative diseases including depression. 29907890 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE The following search items were used: "hypothalamic-pituitary-adrenal" OR "HPA" OR "cortisol" OR "corticotropin releasing hormone" OR "corticotropin releasing factor" OR "glucocorticoid*" OR "adrenocorticotropic hormone" OR "ACTH" AND "atypical depression" OR "non-atypical depression" OR "melancholic depression" OR "non-melancholic depression" OR "endogenous depression" OR "endogenomorphic depression" OR "non-endogenous depression". 29150144 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE In the present study, we demonstrated that chronic FS stress (CFSS) could activate corticotropin-releasing factor (CRF)/CRF receptor type 1 (CRFR1) signaling in the BLA, and blockade of CRF/CRFR1 signaling by intra-BLA injection of NBI27914 (NBI), a selective CRFR1 antagonist, could prevent the CFSS-induced depressive-like behaviors in rats, indicating that activation of CRF/CRFR1 signaling in the BLA is required for CFSS-induced depression. 29080675 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE Serotonin, norepinephrine, dopamine, and trace amines, such as the "endogenous amphetamine" phenylethylamine, are increased in brain, which leads to changes in neuroplasticity by e.g. increased neurotrophic growth factors and translates to reduced stress-induced hypersecretion of corticotropin releasing factor (CRF) and positive testing in animal studies of depression. 28655495 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE Preclinical studies have shown that dysregulation of the corticotropin releasing factor (CRF) neurotransmission has been implicated in stress-related psychopathologies such as depression and anxiety, and may affect alcohol consumption. 29118713 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE These findings suggest that the augmented glutamatergic and synaptic signaling might be a potential mechanism underlying CRH over-activation in the hypothalamic PVN and contribute to CUS-induced depression-like behaviors in rats. 28735061 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE Both cortisol and CRH have behavioral effects, and hypothalamic CRH hypersecretion has been associated with chronic states of anxiety and depression. 28500827 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE i) Compared to control subjects, the amount of hypocretin-immunoreactivity (ir) was significantly increased in female but not in male depression patients; ii) hypothalamic hypocretin-ir showed a clear diurnal fluctuation, which was absent in depression; iii) male depressive patients who had committed suicide showed significantly increased ACC Hcrt-receptor-2-mRNA expression compared to male controls; and iv) female but not male CUMS rats showed a highly significant positive correlation between the mRNA levels of corticotropin-releasing hormone and prepro-hypocretin in the hypothalamus, and a significantly increased Hcrt-receptor-1-mRNA expression in the frontal cortex compared to female control rats. 28377228 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 GeneticVariation disease BEFREE Early life stress (ELS) is associated with increased vulnerability for depression, changes to the corticotropin-releasing hormone (CRH) system and structural and functional changes in hippocampus. 28461011 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE The aim of our study was to assess the influence of SN003, a CRF<sub>1</sub> receptor blocker, on the activity of imipramine and fluoxetine in the forced swim test (FST) in rats which presented some signs of depression. 28429110 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE This paper explores the interactions of glucocorticoids and CRH in the presentation of anxiety and depressive disorders in an effort to better describe their differing roles in each of these clinical presentations. 28119322 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE Clinical application of DEX/CRH test and multi-channel NIRS in patients with depression. 27582123 2016
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease PSYGENET Correlation analysis indicated that the alteration of multiple CRF-controlling receptors is highly correlated with depression-related behaviors of rats in the forced swimming test. 25578258 2015
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease PSYGENET The corticotropin releasing hormone (CRH) and the CRH receptor 1 (CRHR1) have been implicated in the link between early life adversity and adult anxiety and depression, with rodent studies identifying the very early postnatal period as highly susceptible to this programming. 24630468 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease PSYGENET Because dysregulation of CRH expression occurs in stress-related disorders including depression, a full understanding of the complex regulation of this gene is important in both health and disease. 23768074 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease PSYGENET Sensitizing effect of early adversity on depressive reactions to later proximal stress: Moderation by polymorphisms in serotonin transporter and corticotropin releasing hormone receptor genes in a 20-year longitudinal study. 25422958 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease PSYGENET Association of glucocorticoid and type 1 corticotropin-releasing hormone receptors gene variants and risk for depression during pregnancy and post-partum. 23726670 2013