CRH, corticotropin releasing hormone, 1392

N. diseases: 402; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030193
Disease: Pain
Pain
0.380 Biomarker phenotype BEFREE Our previous studies implicated the corticotropin-releasing factor (CRF) system in amygdala plasticity and pain behaviors in an arthritis model. 31489921 2019
CUI: C0030193
Disease: Pain
Pain
0.380 AlteredExpression phenotype BEFREE In the medial prefrontal cortex (mPFC), which is involved in both pain and emotion processing, corticotropin-releasing factor (CRF) expressing neuronal activity was increased in CCI mice. 29780165 2018
CUI: C0030193
Disease: Pain
Pain
0.380 AlteredExpression phenotype BEFREE Corticotropin-releasing factor (CRF), a major mediator in the stress response, is involved in altered function in GI, including inflammatory processes, colonic transit time, contractile activity, defecation pattern, pain threshold, mucosal secretory function, and barrier functions. 29483895 2018
CUI: C0030193
Disease: Pain
Pain
0.380 AlteredExpression phenotype BEFREE Therefore, an over-activation of amygdala CRF neurons is very likely an important contributing factor for pain chronification. 28830762 2017
CUI: C0030193
Disease: Pain
Pain
0.380 Biomarker phenotype BEFREE The corticotropin-releasing factor (CRF) is involved in a number of physiological functions including pain perception. 28434951 2017
CUI: C0030193
Disease: Pain
Pain
0.380 Biomarker phenotype BEFREE The current study examined the effects of SS on nociceptive behaviors and changes in expression of the spinal corticotropin-releasing factor (CRF) system in male Sprague Dawley rats with and without thermal pain. 28979159 2017
CUI: C0030193
Disease: Pain
Pain
0.380 Biomarker phenotype BEFREE In summary, our study demonstrates that CRF plays an important role in the development and maintenance of bone cancer pain via activation of neurons. 26138585 2015
CUI: C0030193
Disease: Pain
Pain
0.380 Therapeutic phenotype CTD_human Our results establish that central CRF is a key modulator of pain behavior and indicates that CRF effects on nociception are largely independent of its mood modulating effect as well as its control of the HPA axis. 16495007 2006
CUI: C0030193
Disease: Pain
Pain
0.380 Biomarker phenotype BEFREE The peripheral paracrine effects of CRF may be similar to those of hypothalamic CRF, i.e., to counterbalance local stressful events, such as inflammation and pain, so that they do not threaten the homeostasis of the body. 9105870 1997