Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Corticotropin-releasing factor 1 receptor haplotype and cognitive features of major depression.
|
29317606 |
2018 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The plasma CRH levels were significantly higher in MDD patients than in controls.
|
28755509 |
2018 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Gene-wide significant results were found for dexamethasone suppression (CYP11A1, CYP17A1, POU1F1, AKR1D1), hippocampal volume (CYP17A1, CYP11A1, HSD3B2, PROP1, AVPRA1, SRD5A1), amygdala volume (POMC, CRH, HSD3B2), and lifetime MDD diagnosis (FKBP5 and CRH), all permutation p-values<0.05.
|
28589964 |
2017 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Forty-five parous (12-24 months postpartum), euthymic women with history of MDD (n = 15), PPD (n = 15), and controls (n = 15) completed pharmacologic (dexamethasone/corticotropin-releasing hormone (CRH) test [DEX/CRH]) and psychological (Trier social stress test [TSST]) challenges during the luteal phase.
|
28251369 |
2017 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
This review presents the current state of knowledge on CRF physiology, and how it may influence the occurrence of symptoms associated with MDD.
|
26271720 |
2015 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although these preliminary observations require further confirmation in future studies, these results on the interaction between CRH haplotypes and SLEs, suggest that CRH ht1 which is moderated by SLEs, may be associated with antidepressant treatment outcomes in patients with MDD.
|
26055202 |
2015 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Negative life events and corticotropin-releasing-hormone receptor1 gene in recurrent major depressive disorder.
|
23529111 |
2013 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The corticotropin-releasing hormone (CRH) system coordinates neuroendocrine and behavioral responses to stress and has been implicated in the development of major depressive disorder (MDD).
|
22378896 |
2012 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The corticotropin-releasing hormone (CRH) system coordinates neuroendocrine and behavioral responses to stress and has been implicated in the development of major depressive disorder (MDD).
|
22378896 |
2012 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
In addition, persistent elevation of cerebrospinal fluid (CSF) corticotropin-releasing factor (CRF) concentrations following early-life adversity has been posited to underlie the subsequent development of major depression.
|
20692103 |
2011 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Within a larger sample of 541 inpatients with major depressive disorder (MDD), we then tested associations of one PPGAL tag SNP with specific depression symptom clusters and HPA-axis activity assessed by the combined dexamethasone-suppression/CRH-stimulation test both at inpatient admission and discharge (n=298).
|
20237460 |
2010 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found reduced mRNA expression of REST and increased mRNA expression of CRH, adenylate cyclase 5, and the tumor necrosis factor superfamily, member 12-13 in patients with major depressive disorder in a current depressive state, but not in a remissive state.
|
19846118 |
2010 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Our results suggest that the aberrant REST-mediated transcriptional regulation of, at least, CRH, adenylate cyclase 5, and tumor necrosis factor superfamily, member 12-13, might be state-dependent and associated with the pathophysiology of major depression.
|
19846118 |
2010 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms.
|
20029939 |
2010 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, we tested whether the polymorphisms of three sites (rs1876828, rs242939 and rs242941) in corticotropin-releasing hormone receptor1 (CRHR1) gene are related to 6 weeks fluoxetine antidepressant effect in 127 Han Chinese patients with MDD.
|
17258395 |
2007 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The subsequent gender analysis showed significant associations of three SNPs (CRF-BPs2 T; CRF-BPs11 T and CRF-BPs12 C) and haplotype G_T_C_T_C with MDD in Swedish males.
|
17599466 |
2007 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Many pieces of evidence supported that corticotropin-releasing hormone (CRH) play a role in the pathophysiology of major depression.
|
16815632 |
2006 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
A function test combining the pre-treatment of 1.5 mg dexamethasone (DEX) with a challenge of 100 microg corticotropin-releasing hormone (CRH) reveals a pathological increase in the adrenocorticotropin and cortisol release in patients with major depression.
|
15504420 |
2005 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
This review focuses on hyperdrive of corticotropin-releasing hormone (CRH) as the fundamental neurobiological correlate of MDD.
|
15196881 |
2004 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recent research suggests that central corticotropin releasing hormone hyperdrive is an important neurobiological risk factor for developing major depression.
|
14573312 |
2003 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
This differential effect of glucocorticoid on CRH mRNA regulation could help explain the abnormal CRH production observed in clinical disorders such as anorexia nervosa and major depression.
|
1547737 |
1992 |