|
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Neither early-life adversity nor CRHR1 blockade in the adult influenced anxiety- or depression-related behaviors.
|
31698409 |
2020 |
|
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
CRF1 and CRF2 receptor antagonists suppressed VacA-induced anxiety and anorexia, respectively.
|
30979915 |
2019 |
|
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Corticotropin-releasing factor binds with high affinity to CRF receptor 1 (CRFR1) and is implicated in stress-related mood disorders such as anxiety and depression.
|
30499109 |
2019 |
|
Anxiety Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
It has been proposed that the common intronic CRHR1 SNP rs110402 is associated with anxiety and cortisol response patterns and plays a key role in vulnerability to certain mental disorders.
|
30447186 |
2019 |
|
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Therefore, the aim of this study was to understand the link between mbTBI and anxiety by examining the impact of mbTBI on the CRFR system in male and female mice. mbTBI increased anxiety-like behaviors in both males and females (p < 0.05).
|
30248435 |
2018 |
|
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
These results suggest that CRF1 antagonists may hold promise as a potential therapy for preventing stress-induced anxiety and memory deficits in aged individuals.
|
29477954 |
2018 |
|
Anxiety Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
CRHR1 gene variation is associated with several mental disorders including anxiety disorders.
|
28233670 |
2017 |
|
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Biochemical, behavioral and genetic studies revealed CRHR1 as a possible candidate gene for mood and anxiety disorders.
|
26324098 |
2016 |
|
Anxiety Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We observed interactions between trait anxiety and rs7209436 and rs110402 in CRHR1 in association with baseline cortisol (p LRT = 0.0272 and p LRT = 0.0483, respectively).
|
23274505 |
2013 |
|
Anxiety Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In conclusion, CRHR1 variation merits investigation in pathophysiology of anxiety and its treatment response.
|
22249355 |
2013 |
|
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
CTD_human |
In MECP2-TG1 animals, reducing the levels of Crh or its receptor, Crhr1, suppressed anxiety-like behavior; in contrast, reducing Oprm1 expression improved abnormal social behavior.
|
22231481 |
2012 |
|
Anxiety Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our data suggest that genetic variants in CRHR1 that associate with differential cortisol activation may also modulate levels of anxiety related to the stress of raising a child with FXS among women who carry an FMR1 premutation.
|
22573456 |
2012 |
|
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Stress and anxiety disorders are risk factors for depression and these behaviors are modulated by corticotrophin-releasing factor receptor 1 (CRFR1) and serotonin receptor (5-HT(2)R).
|
20383137 |
2010 |
|
Anxiety Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In conclusion, this study demonstrates that SP induces CRF1 receptor expression in cells of the CNS, which may be of potential interest for a better understanding of the interplay between SP and the stress hormone axis and, thus, diseases like affective or anxiety disorders.
|
16806114 |
2006 |
|
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The recent characterisation of several selective small-molecule CRHR1 antagonists offers new possibilities for the treatment of anxiety and depression.
|
15310462 |
2004 |
|
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Because CRHR1 affects both depression and anxiety.
|
15365580 |
2004 |
|
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Two subtypes of the corticotropin-releasing factor (CRF) receptor, CRF(1) and CRF(2), differentially modulate brain functions such as anxiety and memory.
|
15192151 |
2004 |
|
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
CTD_human |
The present studies examined the potential functional significance of the CRF2 receptor in relation to the CRF1 receptor using two animal models of anxiety and endocrine reactivity to a stressor.
|
9299637 |
1997 |