Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE DNAm levels within CpG sites in NR3C1, CRH, CRHR1, and CRHR2 were associated with risk for MDD across adolescence and young adulthood. 31582756 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE In contrast, NR3C2, FKBP5 and CRHR1 polymorphisms were not significantly associated with MDD. 27549215 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE Our results strengthen the evidence for the role of CRHR1 SNPs in MDD susceptibility and suggest that their effects may be modulated by sex and smoking status. 27544317 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 AlteredExpression disease BEFREE Recent clinical and preclinical studies, using genetic screening and transgenic rodents, respectively, suggest a major role of the CRF1 gene, and the central expression of CRF1 receptor protein in determining an individual's risk of developing MDD. 26271720 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE The aim of this study was to analyze the possible association of CRHR1 and AVPR1b gene variants with bipolar disorder and major depressive disorder (MDD). 23962971 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease PSYGENET To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV. 23157339 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease PSYGENET Only rs4792888 in CRHR1 showed modest evidence of association with duloxetine response in MDD (P=0.029 in GAD, P=0.054 in MDD). 22249355 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV. 23157339 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease CTD_human These results suggest that the CRHR1 gene could modify the susceptibility to developing recurrent MDD following negative life events in adulthood. 23529111 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease PSYGENET These results suggest that the CRHR1 gene could modify the susceptibility to developing recurrent MDD following negative life events in adulthood. 23529111 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Only rs4792888 in CRHR1 showed modest evidence of association with duloxetine response in MDD (P=0.029 in GAD, P=0.054 in MDD). 22249355 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease PSYGENET The aim of this study was to analyze the possible association of CRHR1 and AVPR1b gene variants with bipolar disorder and major depressive disorder (MDD). 23962971 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE These results suggest that the CRHR1 gene could modify the susceptibility to developing recurrent MDD following negative life events in adulthood. 23529111 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE These results provide support for an association of CRHR1 and CRHR2 with MDD and PD. 22467522 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE CRHR1 was genotyped in 83 controls and a preliminary sample of 16 unmedicated patients with MDD who completed a functional magnetic resonance imaging scan while viewing blocks of positive, negative, and neutral words. 22378896 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease PSYGENET These results provide support for an association of CRHR1 and CRHR2 with MDD and PD. 22467522 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE Allelic association between CRHR1 rs242939 and recurrent MDD was found in our sample (allelic: p = 0.018, genotypic: p = 0.022) with an Odds Ratio 0.454 (95% CI 0.266-0.775). 22194899 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans. 19844206 2009
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE The results support the idea that the CRHR1 gene is likely to be involved in the antidepressant response in MDD. 17258395 2007
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE A nonpeptide CRF1 receptor antagonist has also been shown to reduce symptoms of major depression in an open-label clinical trial. 16122764 2006
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE These results support the idea that the CRHR1 gene is likely to be involved in the genetic vulnerability for major depression. 16815632 2006