Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
DNAm levels within CpG sites in NR3C1, CRH, CRHR1, and CRHR2 were associated with risk for MDD across adolescence and young adulthood.
|
31582756 |
2019 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In contrast, NR3C2, FKBP5 and CRHR1 polymorphisms were not significantly associated with MDD.
|
27549215 |
2017 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results strengthen the evidence for the role of CRHR1 SNPs in MDD susceptibility and suggest that their effects may be modulated by sex and smoking status.
|
27544317 |
2016 |
Major Depressive Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Recent clinical and preclinical studies, using genetic screening and transgenic rodents, respectively, suggest a major role of the CRF1 gene, and the central expression of CRF1 receptor protein in determining an individual's risk of developing MDD.
|
26271720 |
2015 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to analyze the possible association of CRHR1 and AVPR1b gene variants with bipolar disorder and major depressive disorder (MDD).
|
23962971 |
2013 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Only rs4792888 in CRHR1 showed modest evidence of association with duloxetine response in MDD (P=0.029 in GAD, P=0.054 in MDD).
|
22249355 |
2013 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
CTD_human |
These results suggest that the CRHR1 gene could modify the susceptibility to developing recurrent MDD following negative life events in adulthood.
|
23529111 |
2013 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
These results suggest that the CRHR1 gene could modify the susceptibility to developing recurrent MDD following negative life events in adulthood.
|
23529111 |
2013 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Only rs4792888 in CRHR1 showed modest evidence of association with duloxetine response in MDD (P=0.029 in GAD, P=0.054 in MDD).
|
22249355 |
2013 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The aim of this study was to analyze the possible association of CRHR1 and AVPR1b gene variants with bipolar disorder and major depressive disorder (MDD).
|
23962971 |
2013 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the CRHR1 gene could modify the susceptibility to developing recurrent MDD following negative life events in adulthood.
|
23529111 |
2013 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results provide support for an association of CRHR1 and CRHR2 with MDD and PD.
|
22467522 |
2012 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
CRHR1 was genotyped in 83 controls and a preliminary sample of 16 unmedicated patients with MDD who completed a functional magnetic resonance imaging scan while viewing blocks of positive, negative, and neutral words.
|
22378896 |
2012 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
These results provide support for an association of CRHR1 and CRHR2 with MDD and PD.
|
22467522 |
2012 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Allelic association between CRHR1 rs242939 and recurrent MDD was found in our sample (allelic: p = 0.018, genotypic: p = 0.022) with an Odds Ratio 0.454 (95% CI 0.266-0.775).
|
22194899 |
2011 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans.
|
19844206 |
2009 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results support the idea that the CRHR1 gene is likely to be involved in the antidepressant response in MDD.
|
17258395 |
2007 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
A nonpeptide CRF1 receptor antagonist has also been shown to reduce symptoms of major depression in an open-label clinical trial.
|
16122764 |
2006 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results support the idea that the CRHR1 gene is likely to be involved in the genetic vulnerability for major depression.
|
16815632 |
2006 |