Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE Corticotropin-releasing factor binds with high affinity to CRF receptor 1 (CRFR1) and is implicated in stress-related mood disorders such as anxiety and depression. 30499109 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 AlteredExpression disease BEFREE EA treatment can decrease the expression of hypothalamic CRF and CRF-R1, relieve anxiety and depression, meanwhile reduce the expression of CRF-R1 in the gastrointestinal mucosa, increase ZO-1 expression, and adjust tight junctions (TJs) to repair the intestinal mucosal barrier. 31737064 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE Increasing evidence have indicated the strong association of stress, especially the chronic stress and early life stress, with depressive disorders development, while the association of stress with depression is moderated by genetic risk factors, including polymorphism of SERT, BDNF, GR, FKBP5, MR, and CRHR1. 31784962 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE DNAm levels within CpG sites in NR3C1, CRH, CRHR1, and CRHR2 were associated with risk for MDD across adolescence and young adulthood. 31582756 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE These data demonstrate that the CRHR1 TAT haplotype is associated with cognitive features of depression including difficulty with decision-making, higher rumination, and poorer learning and memory. 29317606 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 AlteredExpression disease BEFREE In the present study, we demonstrated that chronic FS stress (CFSS) could activate corticotropin-releasing factor (CRF)/CRF receptor type 1 (CRFR1) signaling in the BLA, and blockade of CRF/CRFR1 signaling by intra-BLA injection of NBI27914 (NBI), a selective CRFR1 antagonist, could prevent the CFSS-induced depressive-like behaviors in rats, indicating that activation of CRF/CRFR1 signaling in the BLA is required for CFSS-induced depression. 29080675 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS to predict depression, cognitive functions and hippocampal activity. 28461011 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE Corticotropin-releasing factor receptor type 1 (CRF1R) is a class B receptor mediating stress response and also considered a drug target for depression and anxiety. 28183242 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 GeneticVariation disease BEFREE In contrast, NR3C2, FKBP5 and CRHR1 polymorphisms were not significantly associated with MDD. 27549215 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker disease BEFREE Our results strengthen the evidence for the role of CRHR1 SNPs in MDD susceptibility and suggest that their effects may be modulated by sex and smoking status. 27544317 2016
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE Growth curve models were executed to determine whether CRHR1 moderated the link between Wave 1 family economic hardship and youths' development of depression. 26206446 2015
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE When all subjects were grouped based on family history of mental illness, there was a statistically significant association of CRHR1 rs242941 with family history regardless of depression status (P = 0.043). 26518448 2015
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease PSYGENET Allelic variants of the glucocorticoid receptor (GR) gene contribute significantly to both cortisol levels and to measures of psychosis; corticotropin-releasing hormone receptor 1 variants contribute to measures of depression and psychosis. 24933348 2015
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE Variants in the corticotropin-releasing hormone receptor 1 (CRHR1) gene have been associated with alcoholism and depression. 25802844 2015
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE Allelic variants of the glucocorticoid receptor (GR) gene contribute significantly to both cortisol levels and to measures of psychosis; corticotropin-releasing hormone receptor 1 variants contribute to measures of depression and psychosis. 24933348 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 AlteredExpression disease BEFREE Recent clinical and preclinical studies, using genetic screening and transgenic rodents, respectively, suggest a major role of the CRF1 gene, and the central expression of CRF1 receptor protein in determining an individual's risk of developing MDD. 26271720 2015
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease PSYGENET Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS experience to predict depression as well as neuroendocrine and neuronal reactivity. 24931706 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE Previous research supports gene-environment interactions for polymorphisms in the corticotropin hormone receptor 1 gene (CRHR1) and the serotonin transporter gene linked polymorphic region (5-HTTLPR) in predicting depression, but it has rarely considered genetic influences on stress sensitization processes, whereby early adversities (EA) increase depressive reactivity to proximal stressors later in life. 25422958 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease PSYGENET Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children. 25422957 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE In addition, GR and corticotropin-releasing hormone receptor 1 (CRHR1) genotypes contributed significantly to psychosis measures and CRHR1 contributed significantly to depression severity rating. 24166410 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease BEFREE The analysed candidate haplotypes in FKBP5, NR3C1, and CRHR1 did not show an association with depression scores as assessed by EPDS in this cohort of healthy unselected pregnant women. 24741566 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease PSYGENET Histone modifications of the Crhr1 gene in a rat model of depression following chronic stress. 24867333 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker disease PSYGENET Previous research supports gene-environment interactions for polymorphisms in the corticotropin hormone receptor 1 gene (CRHR1) and the serotonin transporter gene linked polymorphic region (5-HTTLPR) in predicting depression, but it has rarely considered genetic influences on stress sensitization processes, whereby early adversities (EA) increase depressive reactivity to proximal stressors later in life. 25422958 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS experience to predict depression as well as neuroendocrine and neuronal reactivity. 24931706 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 GeneticVariation disease BEFREE Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children. 25422957 2014