CRMP1, collapsin response mediator protein 1, 1400

N. diseases: 148; N. variants: 42
Disease: Endothelial dysfunction ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.030 AlteredExpression phenotype BEFREE The uremic toxin hippurate promotes endothelial dysfunction via the activation of Drp1-mediated mitochondrial fission. 29573704 2018
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.030 Biomarker phenotype BEFREE Disruption of Drp1 and subsequent mitochondrial fragmentation events prevents impaired vascular dilation, restores mitochondrial phenotype, and implicates mitochondrial fission as a primary mediator of LG-induced endothelial dysfunction.<b>NEW & NOTEWORTHY</b> Acute low-glucose exposure induces mitochondrial fragmentation in endothelial cells via Drp1 and is associated with impaired endothelial function in human arterioles. 27923790 2017
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.030 Biomarker phenotype BEFREE Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction. 26196303 2015